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Table 1 Characteristics of data sources used in the Mendelian randomization study

From: Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study

Traits Data sources Sample size (cases/controls) Ancestry Use
OSA FinnGen [12] 16,761/201,194 European Exposure/Outcome
AF Nielsen et al. [13] 60,620/970,216 European Exposure/Outcome
AF AF HRC [14] 65,446/522,744 Mixed (84.2% European) Outcome for replication analyses
Snoring UK Biobank [15] 152,302/256,015 European Additional analyses
Body mass index Hoffmann et al. [16] 334,487 Mixed (94.3% European) Confounder for MVMR analyses
HTN, SBP, DBP Neale laboratory [17] 317,754 European Confounder for MVMR analyses
Type 2 diabetes Mahajan et al. [18] 74,124/824,006 European Confounder for MVMR analyses
LDL-C, HDL-C, TG Richardson et al. [19] 403,943 ~ 441,016 European Confounder for MVMR analyses
  1. OSA, obstructive sleep apnea; AF, atrial fibrillation; MVMR, multivariable Mendelian randomization; HTN, hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides; AF HRC, Atrial Fibrillation Haplotype Reference Consortium