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Table 2 Causal effects of obstructive sleep apnea on atrial fibrillation from multivariable Mendelian randomization

From: Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study

Exposure Obstructive sleep apnea
Model OR (95% CI) P-value
Unadjusted model 1.210 (1.119–1.307) 1.51 × 10–6
Adjusted for BMI 1.185 (1.083–1.295) 1.98 × 10–4
Adjusted for hypertension 1.221 (1.124–1.327) 2.47 × 10–6
Adjusted for SBP 1.237 (1.097–1.395) 5.36 × 10–4
Adjusted for DBP 1.210 (1.069–1.369) 2.58 × 10–3
Adjusted for T2D 1.146 (1.024–1.283) 1.75 × 10–2
Adjusted for LDL-C 1.149 (1.012–1.305) 3.18 × 10–2
Adjusted for HDL-C 1.172 (1.024–1.341) 2.09 × 10–2
Adjusted for TG 1.284 (1.149–1.435) 1.07 × 10–5
Adjusted for snoring 1.216 (1.059–1.397) 5.55 × 10–3
  1. The results are presented as odds ratios (95% CIs) for the effect of per one-unit increase of log odds of obstructive sleep apnea
  2. OR, odds ratio; CI, confidence interval; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; T2D, type 2 diabetes mellitus; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides