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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Acceleration of the DNA methylation clock among lynch syndrome-associated mutation carriers

Fig. 3

Scatterplot with the estimated methylation age (DNAmAge), against chronological age (Age) of the cases. Patients with Lynch Syndrome-associated mutations are colored in red, except for six patients (colored in green) whose metrics fall within the 95% confidence interval (grey area) of the regression line for the control cases and out of the 95% confidence interval of the regression line for Lynch cases. Cases negative for mutations are highlighted in blue. Regression lines for Lynch/control patients are depicted in red/blue, respectively, but the six Lynch cases highlighted in green are not included in the regression analysis plots. Multiple R2 value for the blue regression line is 0.23 (p value: 0.18). Multiple R2 value for the red regression line is 0.54 (p value: 0.006)

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