Table 2 Results of reanalysis of MDA products with next-generation sequencing
NGS results | Miscarriage cases (n = 28) | Live birth controls (n = 56) | P valuea | OR (95%CI) |
|---|---|---|---|---|
Euploid | 13 (46.4) | 48 (85.7) | < 0.001 | 0.327 (0.185–0.576) |
Whole-chromosome aneuploid | 7 (25.0) | 0 | < 0.001 | |
Mosaic | 5 (17.9) | 5 (8.9) | 0.404 | 1.378 (0.728–2.610) |
Segmental abnormality | 3 (10.7) | 2 (3.6) | 0.327 | 1.709 (0.578–5.052) |
Chaotic | 0 | 1 (1.8) | 0.003 |