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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Comparison of tumor and two types of paratumoral tissues highlighted epigenetic regulation of transcription during field cancerization in non-small cell lung cancer

Fig. 3

Functional annotation of tumor-specific differential methylation regions. GSEA enrichment analyses identified significantly enriched KEGG pathways A extracellular matrix (ECM)-receptor interaction and B focal adhesion among genes [22] with lower DNA methylation level in tumor tissues than in normal tissues. The top 10 enriched GO C biological process, D molecular function, and E cellular component terms consistently showed predominance of terms related to transcriptional regulation and chromatin remodeling

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