Fig. 5

Molecular signatures associated with SPAG1 in AML. a Expression heatmap of differentially expressed genes between AML patients with lower and higher SPAG1 expression groups among TCGA datasets (FDR < 0.05, P < 0.05 and |log2 FC|> 1.5). b Volcano plot of differentially expressed genes between AML patients with lower and higher SPAG1 expression (FDR < 0.05, P < 0.05, and |log2 FC|> 1.5). c Expression heatmap of differentially expressed microRNAs between AML patients with lower and higher SPAG1 expression (FDR < 0.05, P < 0.05, and |log2 FC|> 1.5). d GSEA analysis of SPAG1 expression associated with HOXA9 dysregulation oin AML (NOM P < 0.05 and FDR Q < 0.05)