Table 2 Comparative analysis of SPAG1 expression with clinic-pathologic characteristics in AML

Sex, male/female

46/41

46/40

1.000

Median age, years (range)

57 (18–88)

61 (21–81)

0.409

Median WBC, × 10⁹/L (range)

11 (0.6–297.4)

27.65 (0.4–223.8)

0.014

Median PB blasts, % (range)

41 (0–98)

36 (0–97)

0.544

Median BM blasts, % (range)

70 (32–100)

75 (30–98)

0.377

FAB classifications

0.024

 M0

7

9

NS

 M1

27

17

NS

 M2

21

17

NS

 M3

11

5

NS

 M4

12

22

0.058

 M5

5

13

0.050

 M6

1

1

NS

 M7

3

0

NS

 No data

0

2

NS

Cytogenetics

0.006

 Normal

36

44

NS

 t(15;17)

10

5

NS

 t(8;21)

7

0

0.014

 inv(16)

8

2

NS

 +8

1

7

0.034

 del(5)

1

0

NS

 −7/del(7)

4

3

NS

 11q23

0

3

NS

 Others

7

7

NS

 Complex

11

14

NS

 No data

2

1

NS

Gene mutation

 FLT3 (±)

14/73

35/51

0.000

 NPM1 (±)

20/67

28/58

0.177

 DNMT3A (±)

12/75

30/56

0.001

 IDH2 (±)

10/77

7/79

0.611

 IDH1 (±)

9/78

7/79

0.794

 TET2 (±)

9/78

6/80

0.590

 RUNX1 (±)

8/79

7/79

1.000

 TP53 (±)

6/81

8/78

0.590

 NRAS (±)

6/81

6/80

1.000

 CEBPA (±)

6/81

7/79

0.782

 WT1 (±)

2/85

8/78

0.057

 PTPN11 (±)

4/83

4/82

1.000

 KIT (±)

6/81

1/85

0.117

 U2AF1 (±)

4/83

3/83

1.000

 KRAS (±)

2/85

5/81

0.278