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Table 2 Comparative analysis of SPAG1 expression with clinic-pathologic characteristics in AML

From: Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation

Patient's parameters SPAG1 expression
Low (n = 87) High (n = 86) P value
Sex, male/female 46/41 46/40 1.000
Median age, years (range) 57 (18–88) 61 (21–81) 0.409
Median WBC, × 109/L (range) 11 (0.6–297.4) 27.65 (0.4–223.8) 0.014
Median PB blasts, % (range) 41 (0–98) 36 (0–97) 0.544
Median BM blasts, % (range) 70 (32–100) 75 (30–98) 0.377
FAB classifications    0.024
 M0 7 9 NS
 M1 27 17 NS
 M2 21 17 NS
 M3 11 5 NS
 M4 12 22 0.058
 M5 5 13 0.050
 M6 1 1 NS
 M7 3 0 NS
 No data 0 2 NS
Cytogenetics    0.006
 Normal 36 44 NS
 t(15;17) 10 5 NS
 t(8;21) 7 0 0.014
 inv(16) 8 2 NS
 +8 1 7 0.034
 del(5) 1 0 NS
 −7/del(7) 4 3 NS
 11q23 0 3 NS
 Others 7 7 NS
 Complex 11 14 NS
 No data 2 1 NS
Gene mutation    
 FLT3 (±) 14/73 35/51 0.000
 NPM1 (±) 20/67 28/58 0.177
 DNMT3A (±) 12/75 30/56 0.001
 IDH2 (±) 10/77 7/79 0.611
 IDH1 (±) 9/78 7/79 0.794
 TET2 (±) 9/78 6/80 0.590
 RUNX1 (±) 8/79 7/79 1.000
 TP53 (±) 6/81 8/78 0.590
 NRAS (±) 6/81 6/80 1.000
 CEBPA (±) 6/81 7/79 0.782
 WT1 (±) 2/85 8/78 0.057
 PTPN11 (±) 4/83 4/82 1.000
 KIT (±) 6/81 1/85 0.117
 U2AF1 (±) 4/83 3/83 1.000
 KRAS (±) 2/85 5/81 0.278
  1. AML: acute myeloid leukemia; WBC: white blood cell; PB: peripheral blood; BM: bone marrow; FAB: French-American-British; NS: no significance