Table 1 List of clusters as obtained by MCODE analysis
From: Network analysis of atherosclerotic genes elucidates druggable targets
Cluster | Score (Density*#Nodes) | Nodes | Edges | Node IDs |
|---|---|---|---|---|
1 | 69.631 | 158 | 5466 | VEGFA, VEGFC, AKT1, PDGFRB, STAT3, NLRP3, NOS3, TLR7, CASP3, STAT1, CD28, CD86, JUN, CD40LG, CD40, PTEN, APOB, ESR1, RHOA, APOE, APOA1, HIF1A, TP53, MAPK1, KDR, MAPK3, PTGS2, ACE, AGTR2, FASLG, MMP2, ACKR3, C5, FLT1, BDKRB1, C3, GNB3, GPR55, ANXA5, MTNR1B, GPER1, P2RY12, SUCNR1, IL6R, GRM8, SAA1, IFNG, HCAR2, FPR1, FPR2, CNR1, CASR, APLN, ANXA1, NGF, CCL28, APLNR, CCR2, NPY, CXCR5, CCR5, CXCR6, PPBP, PECAM1, CXCR4, PF4, TLR4, CXCL5, TLR6, CXCL16, CCL5, CXCL1, CXCL12, CXCL8, TNFRSF1A, TNFSF11, MPO, IL18, ELANE, NOTCH1, IL15, ADAM10, LGALS1, SERPIND1, TIMP1, PROC, IGFBP5, FGF23, APOA2, ICAM1, STC2, KITLG, F5, MIA3, VCAM1, QSOX1, APOA5, APOL1, TNC, MMP9, PCSK9, AHSG, SERPINA1, CP, CD44, MMP3, C4A, SPP1, TLR2, IGFBP1, CSF1, TLR1, MFGE8, IGFBP3, CST3, GAS6, PLAU, MMP1, ALB, FN1, IL6, CDH1, ITGB1, BDNF, TNF, HMOX1, IL17A, VWF, CCL2, ADIPOQ, IL10, IL1B, CRP, IDO1, LEP, PPARG, CD68, FOXP3, SELL, INS, CD34, PTPRC, PROM1, ENG, CCL11, TNFSF13B, EDN1, HMGB1, SELE, RELA, ELN, SRC, JAK2, HGF, TGFB1, IGF1, SERPINE1, PLG |
2 | 12.615 | 66 | 410 | KLRK1, BMP2, IGF2, IL9, SOCS3, SIRT1, HBEGF, CAT, JAG1, SELP, SNAI1, GPR29, LCN2, TBX21, MIF, NOS2, MMP10, MMP7, MTOR, CYBB, PLAUR, MMP14, AR, CTNNB1, EGF, IL7R, AGTR1, SOD2, TNFSF10, ADAM17, GPT, CCL17, F3, FCGR2A, IL5, SYK, CDC42, RETN, CCL22, CX3CL1, CD163, ANGPT1, CD69, ANGPT2, PGF, KIT, F2, NFKB1, CXCR2, CX3CR1, CXCR3, SOCS1, HAVCR2, IGF1R, IL33, CDH5, CXCL13, CDKN2A, HSPA4, BGLAP, LGALS3, NOD2, GJA1, IL1A, CLEC7A, IL1RN |
3 | 10.217 | 84 | 424 | CTSB, IL22, IL23R, IL23A, BRCA1, OSM, MMP8, CDKN1B, SOD1, TREM1, HSPA5, KLF4, CAMP, IRS1, TERT, NOX1, NOX4, NCF1, JAK1, DCN, ITGB2, IL2RA, CD4, FOXO1, WNT5A, VLDLR, ILK, AVP, FOXO3, IKBKB, LYN, SELPLG, PLTP, ITGB3, ABCB1, TIMP3, LCAT, B2M, PLAT, TXN, ALOX5, TNFRSF11B, TNFRSF9, NR3C1, AGT, ITGA4, AHR, LPL, GGT2, GCG, VDR, P2RY2, APOA4, SAA2, VIMP, GGT1, CETP, AGER, APOC3, PON1, UTS2, HPR, MSR1, KISS1R, APOC1, GHSR, EDNRA, APOC2, UTS2R, PLA2G7, UTS2B, EDN3, MCAM, KISS1, APOBR, CYSLTR1, EDNRB, LTB4R, LIPC, NFE2L2, APOH, TNFAIP3, COL18A1, TNFSF4 |
4 | 5.3 | 41 | 106 | LEPR, DICER1, CDKN3, PGLYRP1, BMP4, HSPD1, HSPB1, ITGA2B, PTX3, DKK1, ADIPOR1, ITGA2, UCP1, PTH, CHIT1, LIPG, CALCA, HPSE, NEU1, EZH2, CYP19A1, BGN, CD14, SREBF2, NPC1L1, MTTP, DNMT1, EPHA2, SIRT6, ITGAV, CTSK, VIM, SCARB1, ACP5, PPARA, ESR2, STK11, VCL, ABCG8, ABCG5, SREBF1 |
5 | 5.282 | 40 | 103 | CTSL, SCD, GC, NAMPT, UCP2, LTA4H, FADS1, RBP4, FABP4, KLF2, MDK, FGF21, TNFAIP6, ANGPTL3, ADIPOR2, ADM, ANGPTL4, CTSS, HLA-DRB1, MAPK7, HSPG2, GATA2, GHRL, HP, LPA, OLR1, PLCG1, ADRB2, F2R, LDLR, ABCA1, RARRES2, HMGCR, IRS2, NR1H3, ABCG1, ACTA2, NOTCH2, S100A9, NRG1 |
6 | 4.8 | 6 | 12 | LTC4S, TBXAS1, ALOX15, ALOX12, PLA2G6, PLA2G2A |
7 | 3.333 | 4 | 5 | HABP2, F12, HGFAC, PROZ |
8 | 3.333 | 4 | 5 | DHX38, THOC5, HNRNPC, DHX15 |
9 | 3.2 | 6 | 8 | ACSL1, FABP3, CPT1A, NR4A1, UBE2I, NCOA2 |
10 | 3 | 3 | 3 | MSTN, MEF2C, PPARGC1A |
11 | 3 | 7 | 9 | NUMB, CLTCL1, AAK1, PSMA6, PSMD6, SCARB2, LTBR |
12 | 3 | 3 | 3 | ADAMTS3, ADAMTS1, COMP |
13 | 3 | 3 | 3 | NAT2, GSTM1, GSTO1 |
14 | 3 | 3 | 3 | DDAH2, DDAH1, ARG2 |
15 | 3 | 3 | 3 | PAFAH1B2, PLA2G10, PAFAH1B3 |
16 | 3 | 3 | 3 | RNF111, RNF213, HERC6 |
17 | 2.846 | 27 | 37 | ADAMTS4, ADAMTS5, TLN1, ADAMTS13, CAP1, GSTP1, MAN2B1, THBS2, AKR1B1, RIPK2, CHI3L1, PIK3CB, ORMDL3, CD36, CDK5, PLIN2, XDH, ELAVL1, CTSD, YWHAZ, ADAM8, PRDX1, TNFSF12, ARSB, TRAF2, TNFRSF25, CTSC |
18 | 2.667 | 4 | 4 | GLS2, TSHB, GCLC, TXNRD2 |