Fig. 3

Impact on the osteoclastic phenotype of Paget’s disease (PDB) of the SQSTM1 and DOCK6 gene variants. Differentiation of PBMCs into mature osteoclasts (OCL) treated by RANKL and MCSF for 21 days. A Percentage of mature OCL. B Mean number of nuclei per mature OCL. C percentage of bone resorption areas