Skip to main content
Fig. 7 | BMC Medical Genomics

Fig. 7

From: Attenuated clinical and osteoclastic phenotypes of Paget’s disease of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare variant in the DOCK6 gene

Fig. 7

Prediction of the effect of the p.Val45Ile variant in stability and dynamics of DOCK6 by DynaMut2. The predicted interatomic interactions for Val45 (A) and Ile45 (B) residues are shown as sticks along with surrounding residues that are involved in any type of interactions. The p.Val45Ile variant mainly created hydrogen (red dashes) and polar (orange dashes) bonds between Ileu45 and Leu43 (B), and hydrophobic (green dashes) and polar (orange) bonds between Ileu45 and Glu49. In addition, the p.Val45Ile variant broke hydrophobic bonds between Val51 and Val45 (A comparatively to B). Val45 and Ile45 are boxed in green rectangle

Back to article page