Fig. 4

Transcriptome analysis from POU1F1-derived tumors. Panel a shows volcano plot of the differentially expressed genes in POU1F1 from GH-, TSH- and PRL-secreting tumors. Panel b hierarchical cluster from the differentially expressed cyclins and CDK in POU1F1 tumors. Panel c depicts the CDK1 up-regulation in POU1F1 and panel d the lack of mRNA isoforms these in tumors