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Table 5 Generalized multifactor dimensionality reduction analysis of gene–environment interactions and aortic dissection risk

From: Association of gene polymorphisms in FBN1 and TGF-β signaling with the susceptibility and prognostic outcomes of Stanford type B aortic dissection

Model Training bal. acc Testing bal. acc Sign test (p) CV consistency
smoking 0.6920 0.6703 10 (0.0010) 9/10
BMI ≥ 24 kg/m2, smoking 0.7322 0.6907 10 (0.0010) 7/10
FBN1rs201170905, BMI ≥ 24 kg/m2, smoking 0.7597 0.6922 10 (0.0010) 6/10
FBN1rs201170905, BMI ≥ 24 kg/m2, smoking, hypertension 0.7876 0.6912 10 (0.0010) 4/10
FBN1rs201170905, TGFB1rs1800469, TGFB2rs900, BMI ≥ 24 kg/m2, smoking 0.8295 0.6798 10 (0.0010) 8/10
FBN1rs201170905, TGFB1rs1800469, TGFB2rs900, BMI ≥ 24 kg/m2, smoking, hypertension 0.8717 0.7639 10 (0 0010) 9/10
FBN1rs11070646, FBN1rs201170905, TGFB1rs1800469, TGFB2rs900, BMI ≥ 24 kg/m2, smoking, hypertension 0.9078 0.7380 10 (0.0010) 5/10
FBN1rs11070646, FBN1rs201170905, TGFB1rs1800469, TGFB2rs900, BMI ≥ 24 kg/m2, smoking, drinking, hypertension 0.9330 0.7560 10 (0.0010) 10/10
FBN1rs11070646, FBN1rs201170905, TGFB1rs1800469, TGFB2rs900, BMI ≥ 24 kg/m2, dyslipidemia, smoking, drinking, hypertension 0.9539 0.7367 10 (0.0010) 10/10