Fig. 2

Hierarchical clustering of all DEGs which were significantly different between vehicle and high dose WS-CM. All the significant DEGs (log2 fold change > 2 or < -2, and adjusted p-value < 0.05) at 4 h (153 genes) and 24 h (388 genes), as listed in Table 1, were used for hierarchical clustering. In the heatmap, the rows represent expression values for genes, while the columns represent each sample. Low expression is denoted by green and high expression indicated by red. Compared to vehicle control, effect of WS-CM was observed after A 4 h exposure, and B 24 h exposure. N = 4 donors for each treatment; vehicle controls were performed in duplicates