OncoKB alteration | Gene | Tumor site |
---|---|---|
Exon 14 splice mutation | MET | Non-Small Cell Lung Cancer (NSCLC) |
Exon 17 mutations | KIT | Melanoma |
Exon 19 deletion | EGFR | Non-Small Cell Lung Cancer (NSCLC) |
Exon 19 insertion | EGFR | Non-Small Cell Lung Cancer (NSCLC) |
Exon 20 insertion | EGFR | Non-Small Cell Lung Cancer (NSCLC) |
Oncogenic Mutations | KRAS | Colorectal cancer, All solid tumors |
Oncogenic Mutations | NRAS | Colorectal cancer, Melanoma |
Oncogenic Mutations | ALK | NSCLC |
Oncogenic Mutations | BRCA1 | Breast Cancer (BC) |
Oncogenic Mutations | BRCA2 | BC |
Oncogenic Mutations | ERBB2 | BC, NSCLC |
Oncogenic Mutations | FGFR2 | All solid tumors |
Oncogenic Mutations | FGFR3 | All solid tumors |
Oncogenic Mutations | KIT | Melanoma |
Oncogenic Mutations | PIK3CA | BC |
Oncogenic Mutations | TSC1 | CNS |
Oncogenic Mutations | TSC2 | CNS |
Oncogenic Mutations | ARAF | NSCLC |
Oncogenic Mutations | ESR1 | BC |
Oncogenic Mutations | FGFR1 | All solid tumors |
Oncogenic Mutations | MAP2K1 | Melanoma, NSCLC |
Oncogenic Mutations | MTOR | All solid tumors |
Oncogenic Mutations | ATM | All solid tumors |
Oncogenic Mutations | CDKN2A | All solid tumors |
Oncogenic Mutations | NF1 | All solid tumors |
Oncogenic Mutations | PTEN | All solid tumors |
Oncogenic Mutations | SMARCB1 | All solid tumors |