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Table 4 Somatic variant interpretation catalogs by the consensus guidelines and their equivalent on CGI

From: Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows

Class VIC/AMP–ASCO–CAP CGI
I Strong clinical significance Predicted driver
II Potential clinical significance Predicted passenger
III Uncertain significance Known in
IV Benign or likely bening Not protein-affecting or likely neutral for oncogenesis