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Table 3 The top molecular function, biological pathway and cellular component of the 27 genes with no expression in the patients (ToppGene)

From: Intellectual disability associated with craniofacial dysmorphism due to POLR3B mutation and defect in spliceosomal machinery

  ID Name p Value FDR B&H FDR B&Y Bonferroni
GO: molecular function
1 GO:0030627 pre-mRNA 5'-splice site binding 6.55E−13 3.28E−12 7.48E−12 3.28E−12
2 GO:0036002 pre-mRNA binding 1.01E−10 2.52E−10 5.75E−10 5.03E−10
3 GO:0003723 RNA binding 1.08E−04 1.81E−04 4.12E−04 5.42E−04
4 GO:0030622 U4atac snRNA binding 8.24E−04 1.03E−03 2.35E−03 4.12E−03
5 GO:0017069 snRNA binding 1.11E−02 1.11E−02 2.53E−02 5.54E−02
GO: biological process
1 GO:0022618 ribonucleoprotein complex assembly 1.49E−11 1.87E−10 6.81E−10 3.12E−10
2 GO:0071826 ribonucleoprotein complex subunit organization 1.78E−11 1.87E−10 6.81E−10 3.74E−10
3 GO:0000395 mRNA 5'-splice site recognition 5.34E−11 3.74E−10 1.36E−09 1.12E−09
4 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3.69E−10 1.24E−09 4.51E−09 7.76E−09
5 GO:0000398 mRNA splicing, via spliceosome 3.69E−10 1.24E−09 4.51E−09 7.76E−09
GO: cellular component
1 GO:0097525 spliceosomal snRNP complex 2.46E−12 2.72E−11 9.19E−11 3.94E−11
2 GO:0030532 small nuclear ribonucleoprotein complex 3.47E−12 2.72E−11 9.19E−11 5.55E−11
3 GO:0120114 Sm-like protein family complex 5.10E−12 2.72E−11 9.19E−11 8.16E−11
4 GO:1990904 ribonucleoprotein complex 1.97E−08 7.87E−08 2.66E−07 3.15E−07
5 GO:0140513 nuclear protein-containing complex 4.77E−07 1.53E−06 5.16E−06 7.63E−06