Table 5 The potential correlation of NR1H4 mutations with clinical and laboratory data in 197 ICP patients
Characteristics1 | Wild type | Mutation | P value |
|---|---|---|---|
Basic information | |||
 Age (years) | 29.45 ± 5.24 (n = 1912) | 28.50 ± 6.35 (n = 63) | 0.66 |
 Gestational age (days) | 256.29 ± 22.81 (n = 186) | 250.83 ± 37.49 (n = 6) | 0.57 |
 BMI (kg/m2) | 25.89 ± 3.94 (n = 177) | 23.80 ± 2.83 (n = 6) | 0.14 |
 Gravidity (times) | 2.39 ± 1.53 (n = 183) | 2.67 ± 2.25 (n = 6) | 0.67 |
 Parity (times) | 0.63 ± 0.75 (n = 182) | 0.83 ± 1.60 (n = 6) | 0.52 |
Serum biochemical index | |||
 K (mmol/L) | 4.01 ± 0.36 (n = 181) | 4.08 ± 0.21 (n = 6) | 0.63 |
 Na (mmol/L) | 137.27 ± 2.15 (n = 180) | 139.50 ± 3.02 (n = 6) | 0.014* |
 CL (mmol/L) | 104.04 ± 2.61 (n = 180) | 105.00 ± 2.97 (n = 6) | 0.38 |
 Ca (mmol/L) | 2.36 ± 0.17 (n = 180) | 2.30 ± 0.14 (n = 6) | 0.37 |
 Mg (mmol/L) | 0.81 ± 0.14 (n = 180) | 0.81 ± 0.08 (n = 6) | 0.87 |
 P (mmol/L) | 1.15 ± 0.19 (n = 180) | 1.10 ± 0.18 (n = 6) | 0.55 |
 WBC (× 109) | 8.56 ± 2.64 (n = 190) | 8.43 ± 4.58 (n = 6) | 0.91 |
 RBC (× 1012) | 3.84 ± 0.42 (n = 190) | 3.67 ± 0.30 (n = 6) | 0.32 |
 PLT (× 109) | 197.56 ± 59.10 (n = 190) | 204.00 ± 54.36 (n = 6) | 0.79 |
 RDW-SD (fL) | 46.03 ± 4.83 (n = 190) | 48.20 ± 5.81 (n = 6) | 0.28 |
 ALT (U/L) | 104.40 ± 128.54 (n = 191) | 62.83 ± 70.74 (n = 6) | 0.43 |
 AST (U/L) | 88.00 ± 99.84 (n = 191) | 62.83 ± 67.00 (n = 6) | 0.54 |
 TBA (μmol/L) | 42.46 ± 38.25 (n = 191) | 44.07 ± 36.68 (n = 6) | 0.92 |
 TBIL (μmol/L) | 14.95 ± 7.48 (n = 189) | 15.03 ± 8.29 (n = 6) | 0.98 |
 DBIL (μmol/L) | 6.93 ± 6.10 (n = 189) | 7.93 ± 7.26 (n = 6) | 0.69 |
 IDBIL (μmol/L) | 8.04 ± 3.51 (n = 189) | 7.10 ± 2.69 (n = 6) | 0.52 |
 CHOL (mmol/L) | 6.39 ± 1.69 (n = 183) | 6.13 ± 0.69 (n = 6) | 0.69 |
 TG (mmol/L) | 3.62 ± 1.59 (n = 183) | 3.31 ± 0.99 (n = 6) | 0.63 |
 HDL (mmol/L) | 1.94 ± 0.50 (n = 183) | 1.98 ± 0.35 (n = 6) | 0.84 |
 LDL (mmol/L) | 2.80 ± 1.33 (n = 183) | 2.64 ± 0.24 (n = 6) | 0.77 |
 UA (μmol/L) | 327.54 ± 91.69 (n = 181) | 294.67 ± 96.65 (n = 6) | 0.39 |
Outcomes of pregnancy women and newborn baby | |||
 Birth weight (kg) | 3.06 ± 0.75 (n = 155) | 3.55 ± 0.39 (n = 4) | 0.09 |
 Apgar score (1–10) | 9.40 ± 1.25 (n = 154) | 9.00 ± 0.82 (n = 4) | 0.24 |
 Bleeding count (mL) | 260.82 ± 102.76 (n = 153) | 316.67 ± 170.17 (n = 3) | 0.32 |