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Table 5 The potential correlation of NR1H4 mutations with clinical and laboratory data in 197 ICP patients

From: Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients

Characteristics1 Wild type Mutation P value
Basic information
 Age (years) 29.45 ± 5.24 (n = 1912) 28.50 ± 6.35 (n = 63) 0.66
 Gestational age (days) 256.29 ± 22.81 (n = 186) 250.83 ± 37.49 (n = 6) 0.57
 BMI (kg/m2) 25.89 ± 3.94 (n = 177) 23.80 ± 2.83 (n = 6) 0.14
 Gravidity (times) 2.39 ± 1.53 (n = 183) 2.67 ± 2.25 (n = 6) 0.67
 Parity (times) 0.63 ± 0.75 (n = 182) 0.83 ± 1.60 (n = 6) 0.52
Serum biochemical index
 K (mmol/L) 4.01 ± 0.36 (n = 181) 4.08 ± 0.21 (n = 6) 0.63
 Na (mmol/L) 137.27 ± 2.15 (n = 180) 139.50 ± 3.02 (n = 6) 0.014*
 CL (mmol/L) 104.04 ± 2.61 (n = 180) 105.00 ± 2.97 (n = 6) 0.38
 Ca (mmol/L) 2.36 ± 0.17 (n = 180) 2.30 ± 0.14 (n = 6) 0.37
 Mg (mmol/L) 0.81 ± 0.14 (n = 180) 0.81 ± 0.08 (n = 6) 0.87
 P (mmol/L) 1.15 ± 0.19 (n = 180) 1.10 ± 0.18 (n = 6) 0.55
 WBC (× 109) 8.56 ± 2.64 (n = 190) 8.43 ± 4.58 (n = 6) 0.91
 RBC (× 1012) 3.84 ± 0.42 (n = 190) 3.67 ± 0.30 (n = 6) 0.32
 PLT (× 109) 197.56 ± 59.10 (n = 190) 204.00 ± 54.36 (n = 6) 0.79
 RDW-SD (fL) 46.03 ± 4.83 (n = 190) 48.20 ± 5.81 (n = 6) 0.28
 ALT (U/L) 104.40 ± 128.54 (n = 191) 62.83 ± 70.74 (n = 6) 0.43
 AST (U/L) 88.00 ± 99.84 (n = 191) 62.83 ± 67.00 (n = 6) 0.54
 TBA (μmol/L) 42.46 ± 38.25 (n = 191) 44.07 ± 36.68 (n = 6) 0.92
 TBIL (μmol/L) 14.95 ± 7.48 (n = 189) 15.03 ± 8.29 (n = 6) 0.98
 DBIL (μmol/L) 6.93 ± 6.10 (n = 189) 7.93 ± 7.26 (n = 6) 0.69
 IDBIL (μmol/L) 8.04 ± 3.51 (n = 189) 7.10 ± 2.69 (n = 6) 0.52
 CHOL (mmol/L) 6.39 ± 1.69 (n = 183) 6.13 ± 0.69 (n = 6) 0.69
 TG (mmol/L) 3.62 ± 1.59 (n = 183) 3.31 ± 0.99 (n = 6) 0.63
 HDL (mmol/L) 1.94 ± 0.50 (n = 183) 1.98 ± 0.35 (n = 6) 0.84
 LDL (mmol/L) 2.80 ± 1.33 (n = 183) 2.64 ± 0.24 (n = 6) 0.77
 UA (μmol/L) 327.54 ± 91.69 (n = 181) 294.67 ± 96.65 (n = 6) 0.39
Outcomes of pregnancy women and newborn baby
 Birth weight (kg) 3.06 ± 0.75 (n = 155) 3.55 ± 0.39 (n = 4) 0.09
 Apgar score (1–10) 9.40 ± 1.25 (n = 154) 9.00 ± 0.82 (n = 4) 0.24
 Bleeding count (mL) 260.82 ± 102.76 (n = 153) 316.67 ± 170.17 (n = 3) 0.32
  1. 1Abbreviations refer to the footnotes in Table 1
  2. 2The total number of patients for wild type group
  3. 3The total number of patients for mutation group
  4. 4*P < 0.05, the level of Na ion was significantly difference between wild-type group and mutation group