|
Characteristics1
|
Wild type
|
Mutation
|
P value
|
|---|
|
Basic information
|
|
Age (years)
|
29.45 ± 5.24 (n = 1912)
|
28.50 ± 6.35 (n = 63)
|
0.66
|
|
Gestational age (days)
|
256.29 ± 22.81 (n = 186)
|
250.83 ± 37.49 (n = 6)
|
0.57
|
|
BMI (kg/m2)
|
25.89 ± 3.94 (n = 177)
|
23.80 ± 2.83 (n = 6)
|
0.14
|
|
Gravidity (times)
|
2.39 ± 1.53 (n = 183)
|
2.67 ± 2.25 (n = 6)
|
0.67
|
|
Parity (times)
|
0.63 ± 0.75 (n = 182)
|
0.83 ± 1.60 (n = 6)
|
0.52
|
|
Serum biochemical index
|
|
K (mmol/L)
|
4.01 ± 0.36 (n = 181)
|
4.08 ± 0.21 (n = 6)
|
0.63
|
|
Na (mmol/L)
|
137.27 ± 2.15 (n = 180)
|
139.50 ± 3.02 (n = 6)
|
0.014*
|
|
CL (mmol/L)
|
104.04 ± 2.61 (n = 180)
|
105.00 ± 2.97 (n = 6)
|
0.38
|
|
Ca (mmol/L)
|
2.36 ± 0.17 (n = 180)
|
2.30 ± 0.14 (n = 6)
|
0.37
|
|
Mg (mmol/L)
|
0.81 ± 0.14 (n = 180)
|
0.81 ± 0.08 (n = 6)
|
0.87
|
|
P (mmol/L)
|
1.15 ± 0.19 (n = 180)
|
1.10 ± 0.18 (n = 6)
|
0.55
|
|
WBC (× 109)
|
8.56 ± 2.64 (n = 190)
|
8.43 ± 4.58 (n = 6)
|
0.91
|
|
RBC (× 1012)
|
3.84 ± 0.42 (n = 190)
|
3.67 ± 0.30 (n = 6)
|
0.32
|
|
PLT (× 109)
|
197.56 ± 59.10 (n = 190)
|
204.00 ± 54.36 (n = 6)
|
0.79
|
|
RDW-SD (fL)
|
46.03 ± 4.83 (n = 190)
|
48.20 ± 5.81 (n = 6)
|
0.28
|
|
ALT (U/L)
|
104.40 ± 128.54 (n = 191)
|
62.83 ± 70.74 (n = 6)
|
0.43
|
|
AST (U/L)
|
88.00 ± 99.84 (n = 191)
|
62.83 ± 67.00 (n = 6)
|
0.54
|
|
TBA (μmol/L)
|
42.46 ± 38.25 (n = 191)
|
44.07 ± 36.68 (n = 6)
|
0.92
|
|
TBIL (μmol/L)
|
14.95 ± 7.48 (n = 189)
|
15.03 ± 8.29 (n = 6)
|
0.98
|
|
DBIL (μmol/L)
|
6.93 ± 6.10 (n = 189)
|
7.93 ± 7.26 (n = 6)
|
0.69
|
|
IDBIL (μmol/L)
|
8.04 ± 3.51 (n = 189)
|
7.10 ± 2.69 (n = 6)
|
0.52
|
|
CHOL (mmol/L)
|
6.39 ± 1.69 (n = 183)
|
6.13 ± 0.69 (n = 6)
|
0.69
|
|
TG (mmol/L)
|
3.62 ± 1.59 (n = 183)
|
3.31 ± 0.99 (n = 6)
|
0.63
|
|
HDL (mmol/L)
|
1.94 ± 0.50 (n = 183)
|
1.98 ± 0.35 (n = 6)
|
0.84
|
|
LDL (mmol/L)
|
2.80 ± 1.33 (n = 183)
|
2.64 ± 0.24 (n = 6)
|
0.77
|
|
UA (μmol/L)
|
327.54 ± 91.69 (n = 181)
|
294.67 ± 96.65 (n = 6)
|
0.39
|
|
Outcomes of pregnancy women and newborn baby
|
|
Birth weight (kg)
|
3.06 ± 0.75 (n = 155)
|
3.55 ± 0.39 (n = 4)
|
0.09
|
|
Apgar score (1–10)
|
9.40 ± 1.25 (n = 154)
|
9.00 ± 0.82 (n = 4)
|
0.24
|
|
Bleeding count (mL)
|
260.82 ± 102.76 (n = 153)
|
316.67 ± 170.17 (n = 3)
|
0.32
|
- 1Abbreviations refer to the footnotes in Table 1
- 2The total number of patients for wild type group
- 3The total number of patients for mutation group
- 4*P < 0.05, the level of Na ion was significantly difference between wild-type group and mutation group
