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Table 3 Diagnostic performance of ProCAD by incorporating all chromosomes

From: Copy number variation of urine exfoliated cells by low-coverage whole genome sequencing for diagnosis of prostate adenocarcinoma: a prospective cohort study

 

AUC (95% CI)

Cutoff

TN

TP

FN

FP

PPV (%)

NPV (%)

Specificity (%)

Sensitivity (%)

Accuracy (%)

ProCAD CHR1-22

0.91 (0.83, 0.99)

2

3

15

1

6

71.4

75.0

33.3

93.8

72.0

  

2.5

9

13

3

0

100.0

75.0

100.0

81.3

88.0

  

3

9

8

8

0

100.0

52.9

100.0

50.0

68.0

f/t PSA (%)

0.63 (0.42, 0.83)

< 10%

7

9

7

2

81.8

50.0

77.8

56.3

64.0

  

< 16%

4

11

5

5

68.8

44.4

44.4

68.8

60.0

  1. ProCAD versus f/t PSA, P = 0.012