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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Integrated investigation of DNA methylation, gene expression and immune cell population revealed immune cell infiltration associated with atherosclerotic plaque formation

Fig. 3

The dynamics of cell population in atherosclerotic carotid plaques and PBMCs. (A) Bar plot showing the fractions of immune cell types estimated by CIBERSORT in plaque and PBMCs groups. ***p value < 0.001, unpaired t-test. (B) Principal component analysis (PCA) of samples based on the proportion of different cell types. The samples were grouped by disease state. The ellipse for each group is the confidence ellipse. (C) Dot plot showing the fraction changes (X-axis, log2 fold changes, log2FC) and statistical p-values (Y-axis, -log10P-value) of immune cell types between plaque and PBMCs. (D) Scatter box plots showing the proportion of resting and activated mast cells in atherosclerotic carotid plaques and PBMCs. (E) The same with D but for the resting and activated NK cells. (F) The same with D but for the resting and activated DC cells. (G) The same with D but for the T follicular helper cells. (H) The same with D but for the Eosinophils cells

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BMC Medical Genomics

ISSN: 1755-8794

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