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Fig. 2 | BMC Medical Genomics

Fig. 2

From: HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC)

Fig. 2

HBV integration heterogeneity and mechanisms of HBV integration. A Fractions of cells in each tissue with or without HBV sequences detected. B Circos map of integration; each circle indicates integrations identified in a tumor tissue. C HBV integration distribution across the human genome. Each row represents the integration profile of a cell. The cells are labeled by its tissue source. The columns are loci with HBV integrations along chromosomes. The cells were clustered by hierarchical clustering. D An example of Microhomolog between sequences of the human genome and HBV genome at an HBV integration hotspot site Chr1 34,307,059. There are two 4 bp homologs between human genome and HBV genome (AGAG and TGAA) with 1 bp mismatch in the middle. E Microhomology enrichment. Numbers of HBV integrations carrying different length of homology sequences between human genome and HBV genome near the HBV integration sites were collected (blue). The observed numbers were significantly different from the numbers based on random simulations (red). F Fragile region enrichment. Both common and rare fragile regions on the human genome were enriched for HBV integrations

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