Fig. 4

Clonal relationship of cells from different tumor sites. A A phylogenetic tree built based on single cell CNV profiles. Each node corresponds to a cell. The cells are colored according clone annotation. Splitting nodes are marked as squared nodes. The scale of splitting node correlates to the number of its decedent nodes. B Clone composition of each tumor tissue. Pie plots for each bin on the fractions of four clones. Each tumor tissue had one major clone and three minor clones. There was no single major clone in the thrombus tissues, but clones 3 and 4 together accounted for more than 50% of cells in the tumor thrombi, suggesting the two clones were more invasive