Fig. 5From: HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC)Simulation of clonal evolution with only CNVs. A The scheme of birth–death clonal evolution model. Cells accumulated CNVs during cell growth. Each additional CNV increased cell’s probability to divide over to die. B Cell populations/tumors were simulated with different combinations of mutation rates (MRs) and selection coefficients (SCs). The posterior probability of each parameter combination was calculatedBack to article page