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Table 1 Functional enrichment of genes in the CNV blocks that were significantly different between clone1 and clones 2–4

From: HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC)

Category Term overlap Genes Fold Enrichment P-value FDR
INTERPRO Secretoglobin SCGB1A1,SCGB1D1,SCGB1D2, SCGB1D4,SCGB2A1,SCGB2A2 50.9 5.8E−8 8E−5
UP_KEYWORDS HDL APOA1,APOA4,APOA5, SAA1,SAA2,SAA4 32 8.5E−7 1.1E−3
SMART CARD CASP1, CASP4, CASP5, CARD16, CARD17 48.2 2.3E−6 2.5E−3
SMART SAA SAA2-SAA4, SAA1, SAA2, SAA4 115.6 2.4E−6 2.6E−3
GOTERM_CC_DIRECT High-density lipoprotein particle APOA1,APOA4,APOA5, SAA1,SAA2,SAA4 23.9 4.1E−6 5.2E−3
INTERPRO Serum amyloid A protein SAA2-SAA4, SAA1, SAA2, SAA4 93.3 4.7E−6 6.6E−3
INTERPRO Caspase Recruitment CASP1, CASP12, CASP4, CASP5, CARD16, CARD17 19.3 1.3E−5 1.8E−2
GOTERM_CC_DIRECT IPAF inflammasome complex CASP1, CASP12, CASP4, CASP5 70.1 1.4E−5 1.8E−2
GOTERM_CC_DIRECT AIM2 inflammasome complex CASP1, CASP12, CASP4, CASP5 58.4 2.8E−5 3.6E−2
GOTERM_MF_DIRECT Sodium-independent organic anion transmembrane transporter activity SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLCO2B1 22.2 6.5E−5 8.9E−2
GOTERM_CC_DIRECT NLRP3 inflammasome complex CASP1, CASP12, CASP4, CASP5 43.8 7.8E−5 9.9E−2
GOTERM_BP_DIRECT Sodium-independent organic anion transport SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLCO2B1 20.1 9.9E−5 1.5E−1
GOTERM_BP_DIRECT Regulation of apoptotic process ALX4, CD3E, CASP1, CASP12, CASP4, CASP5, CARD16, CARD17, RPS3, ROBO4, TP53AIP1 4.8 1.1E−4 1.7E−1
SMART CASc CASP1, CASP12, CASP4, CASP5 35.6 1.6E−4 1.8E−1
  1. A total of 370 genes were in the regions. DAVID(43) was used to test functional enrichment