Table 1 Functional enrichment of genes in the CNV blocks that were significantly different between clone1 and clones 2–4

INTERPRO

Secretoglobin

SCGB1A1,SCGB1D1,SCGB1D2, SCGB1D4,SCGB2A1,SCGB2A2

50.9

5.8E−8

8E−5

UP_KEYWORDS

HDL

APOA1,APOA4,APOA5, SAA1,SAA2,SAA4

32

8.5E−7

1.1E−3

SMART

CARD

CASP1, CASP4, CASP5, CARD16, CARD17

48.2

2.3E−6

2.5E−3

SMART

SAA

SAA2-SAA4, SAA1, SAA2, SAA4

115.6

2.4E−6

2.6E−3

GOTERM_CC_DIRECT

High-density lipoprotein particle

APOA1,APOA4,APOA5, SAA1,SAA2,SAA4

23.9

4.1E−6

5.2E−3

INTERPRO

Serum amyloid A protein

SAA2-SAA4, SAA1, SAA2, SAA4

93.3

4.7E−6

6.6E−3

INTERPRO

Caspase Recruitment

CASP1, CASP12, CASP4, CASP5, CARD16, CARD17

19.3

1.3E−5

1.8E−2

GOTERM_CC_DIRECT

IPAF inflammasome complex

CASP1, CASP12, CASP4, CASP5

70.1

1.4E−5

1.8E−2

GOTERM_CC_DIRECT

AIM2 inflammasome complex

CASP1, CASP12, CASP4, CASP5

58.4

2.8E−5

3.6E−2

GOTERM_MF_DIRECT

Sodium-independent organic anion transmembrane transporter activity

SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLCO2B1

22.2

6.5E−5

8.9E−2

GOTERM_CC_DIRECT

NLRP3 inflammasome complex

CASP1, CASP12, CASP4, CASP5

43.8

7.8E−5

9.9E−2

GOTERM_BP_DIRECT

Sodium-independent organic anion transport

SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLCO2B1

20.1

9.9E−5

1.5E−1

GOTERM_BP_DIRECT

Regulation of apoptotic process

ALX4, CD3E, CASP1, CASP12, CASP4, CASP5, CARD16, CARD17, RPS3, ROBO4, TP53AIP1

4.8

1.1E−4

1.7E−1

SMART

CASc

CASP1, CASP12, CASP4, CASP5

35.6

1.6E−4

1.8E−1