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Table 4 The methylation status of six target promoter regions in VDR, CasR, CLDN14 when methylation is defined in three subgroups of the Unmethylated (methylation < 9%), and Methylated (methylation ≥ 9%)

From: The correlation between promoter hypermethylation of VDR, CLDN, and CasR genes and recurrent stone formation

Gene

Recurrent stone formers (N = 30)

Control (N = 30)

p-value

VDRa

Unmethylated

2 (6.7%)

12(42.9%)

0.001*

Methylated

28(93.3%)

16(57.1%)

VDRb

Unmethylated

1(3.4%)

10(34.5%)

0.005*

Methylated

28(96.6%)

19(65.5%)

CLDNa

Unmethylated

4(14.8%)

15(50.0%)

0.005*

Hypermethylated

23(85.2%)

15(50.0%)

CLDNb

Unmethylated

4(14.8%)

13(43.3%)

 < 0.019*

Methylated

23(85.2%)

17(56.7%)

CasRa

unmethylated

2(7.1%)

6(20.0%)

 < 0.256**

Methylated

26(92.9%)

24(80.0%)

CasRb

Unmethylated

1(3.4%)

6(20.0%)

 < 0.150**

Methylated

26(92.9%)

24(80.0%)

  1. The methylation status was not associated with the age and gender of recurrent stone formers (Table 5)