Skip to main content

Table 4 The methylation status of six target promoter regions in VDR, CasR, CLDN14 when methylation is defined in three subgroups of the Unmethylated (methylation < 9%), and Methylated (methylation ≥ 9%)

From: The correlation between promoter hypermethylation of VDR, CLDN, and CasR genes and recurrent stone formation

Gene Recurrent stone formers (N = 30) Control (N = 30) p-value
VDRa Unmethylated 2 (6.7%) 12(42.9%) 0.001*
Methylated 28(93.3%) 16(57.1%)
VDRb Unmethylated 1(3.4%) 10(34.5%) 0.005*
Methylated 28(96.6%) 19(65.5%)
CLDNa Unmethylated 4(14.8%) 15(50.0%) 0.005*
Hypermethylated 23(85.2%) 15(50.0%)
CLDNb Unmethylated 4(14.8%) 13(43.3%)  < 0.019*
Methylated 23(85.2%) 17(56.7%)
CasRa unmethylated 2(7.1%) 6(20.0%)  < 0.256**
Methylated 26(92.9%) 24(80.0%)
CasRb Unmethylated 1(3.4%) 6(20.0%)  < 0.150**
Methylated 26(92.9%) 24(80.0%)
  1. The methylation status was not associated with the age and gender of recurrent stone formers (Table 5)