Fig. 2

Cystoscopic, imaging, and pathological examination results and genomic sequencing in Case 2. a Bladder magnetic resonance imaging. b Pelvic computed tomography. Non-muscle-invasive masses in the neck and posterior wall of the urinary bladder are shown. c, d Cystoscopic findings. The tumor invaded from the prostate gland and has obstructed the bladder neck (c) and nodular masses are shown at the left posterior bladder wall (d). e–h Representative microscopic images of hematoxylin and eosin (HE) staining and prostate-specific antigen, androgen receptor, and synaptophysin immunohistochemical staining and transurethral resection of the bladder tumor specimens. These images were obtained using the following equipment: microscope, BX53; objective lens, UPLXAPO; camera, DP27; adapter, U-TV1XC. NanoZoomer-XR C12000 was used as acquisition software and the measured resolution was 500 dpi. i Examined genes (horizontal axis) and the copy number in Case 2 (vertical axis)