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Table 2 Association of copy number variants with risk of asthma in UK Biobank

From: Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

Chrom Start End Genes Stage 1 Meta-analysis stages 1 and 2
OR 95% CI P value OR 95% CI P value
1 16922018 16948926 CROCC 0.96 0.93–0.99 0.0222 1.00 0.98–1.01 0.6280
1 120823308 120890315 NBPF26/PPIAL4A/RNVU1-19 0.95 0.92–0.99 0.0121 0.98 0.96–1.00 0.1011
2 178432096 178444500 CHROMR/PRKRA 1.18 1.14–1.23 1.54 × 10–15 1.13 1.11–1.15 3.67 × 10–29
5 71011274 71055457 GTF2H2/GTF2H2C/GTF2H2C_2/NAIP 0.93 0.90–0.97 0.0014 0.97 0.95–1.00 0.0189
5 139325439 139325662 MATR3 1.19 1.04–1.35 0.0100 1.03 0.96–1.11 0.3763
6 31026054 31027714 MUC22 1.16 1.09–1.23 1.38 × 10–6 1.07 1.04–1.10 1.25 × 10–5
6 31995912 31996634 C4A/C4B/C4B_2/LOC110384692 0.94 0.91–0.97 0.0005 0.97 0.95–0.99 0.0008
6 32641971 32666607 HLA-DQA1/HLA-DQB1/HLA-DQB1-AS1 0.83 0.80–0.87 3.62 × 10–19 0.85 0.83–0.86 1.95 × 10–57
6 32827709 32828045 TAP2 1.10 1.06–1.15 4.67 × 10–6 1.10 1.07–1.12 4.60 × 10–16
11 1242887 1243906 MUC5B/MUC5B-AS1 1.15 1.02–1.29 0.0186 1.15 1.03–1.28 0.0117
11 1250234 1251240 MUC5B 1.18 1.06–1.31 0.0026 1.18 1.07–1.31 0.0013
12 52692420 52692880 KRT77 0.90 0.84–0.96 0.0010 0.95 0.92–0.99 0.0055
12 132507235 132511952 FBRSL1 1.08 1.03–1.14 0.0032 1.08 1.05–1.11 2.71 × 10–7
14 23965761 23965983 DHRS4 0.91 0.84–0.98 0.0121 0.96 0.92–1.00 0.0757
16 20480572 20480700 ACSM2A 0.94 0.90–0.99 0.0207 0.99 0.96–1.01 0.2713
19 49959359 49960938 SIGLEC11 1.15 1.01–1.30 0.0327 1.06 0.99–1.13 0.0906
19 54825027 54842918 KIR gene region* 1.06 1.02–1.11 0.0067 1.03 1.01–1.06 0.0060
  1. P values in bold exceed a Bonferroni-corrected threshold
  2. *KIR2DS1/KIR2DS2/KIR2DS3/KIR2DS4/KIR2DS5/KIR3DL1/KIR3DS1/LOC101928804/LOC102725023/LOC112268355