Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

Table 2 Association of copy number variants with risk of asthma in UK Biobank

Chrom	Start	End	Genes	Stage 1			Meta-analysis stages 1 and 2
Chrom	Start	End	Genes	OR	95% CI	P value	OR	95% CI	P value
1	16922018	16948926	CROCC	0.96	0.93–0.99	0.0222	1.00	0.98–1.01	0.6280
1	120823308	120890315	NBPF26/PPIAL4A/RNVU1-19	0.95	0.92–0.99	0.0121	0.98	0.96–1.00	0.1011
2	178432096	178444500	CHROMR/PRKRA	1.18	1.14–1.23	1.54 × 10^–15	1.13	1.11–1.15	3.67 × 10^–29
5	71011274	71055457	GTF2H2/GTF2H2C/GTF2H2C_2/NAIP	0.93	0.90–0.97	0.0014	0.97	0.95–1.00	0.0189
5	139325439	139325662	MATR3	1.19	1.04–1.35	0.0100	1.03	0.96–1.11	0.3763
6	31026054	31027714	MUC22	1.16	1.09–1.23	1.38 × 10^–6	1.07	1.04–1.10	1.25 × 10^–5
6	31995912	31996634	C4A/C4B/C4B_2/LOC110384692	0.94	0.91–0.97	0.0005	0.97	0.95–0.99	0.0008
6	32641971	32666607	HLA-DQA1/HLA-DQB1/HLA-DQB1-AS1	0.83	0.80–0.87	3.62 × 10^–19	0.85	0.83–0.86	1.95 × 10^–57
6	32827709	32828045	TAP2	1.10	1.06–1.15	4.67 × 10^–6	1.10	1.07–1.12	4.60 × 10^–16
11	1242887	1243906	MUC5B/MUC5B-AS1	1.15	1.02–1.29	0.0186	1.15	1.03–1.28	0.0117
11	1250234	1251240	MUC5B	1.18	1.06–1.31	0.0026	1.18	1.07–1.31	0.0013
12	52692420	52692880	KRT77	0.90	0.84–0.96	0.0010	0.95	0.92–0.99	0.0055
12	132507235	132511952	FBRSL1	1.08	1.03–1.14	0.0032	1.08	1.05–1.11	2.71 × 10^–7
14	23965761	23965983	DHRS4	0.91	0.84–0.98	0.0121	0.96	0.92–1.00	0.0757
16	20480572	20480700	ACSM2A	0.94	0.90–0.99	0.0207	0.99	0.96–1.01	0.2713
19	49959359	49960938	SIGLEC11	1.15	1.01–1.30	0.0327	1.06	0.99–1.13	0.0906
19	54825027	54842918	KIR gene region*	1.06	1.02–1.11	0.0067	1.03	1.01–1.06	0.0060

P values in bold exceed a Bonferroni-corrected threshold
^*KIR2DS1/KIR2DS2/KIR2DS3/KIR2DS4/KIR2DS5/KIR3DL1/KIR3DS1/LOC101928804/LOC102725023/LOC112268355

ISSN: 1755-8794