Fig. 4

Alterations in the PI3K/AKT signaling pathway in GS tissue. a Brief representation of gene members in the PI3K/AKT pathway. Most genes showed changes in expression when comparing adjacent normal to GS tissue affecting other metabolic pathways. b Heatmap representation of the gene members affected by RNA-seq expression changes between normal and GS tissue. PTEN and MDM2 showed over-expression in GS tissue while most of the other affected genes appear down-regulated when compared to adjacent normal