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Table 2 The information about FTO SNPs and the association with ONFH susceptibility in allele model

From: FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

SNPs ID Chr: position Alleles
(minor/major)
Frequency (MAF) Function P value for HWE Call rate OR (95% CI) P Haploreg Regulome DB
Case Control Control Case
rs9930333 16:53,766,065 G/T 0.154 0.157 Intronic 0.610 0.105 99.8% 0.98 (0.77–1.25) 0.853 Enhancer histone marks, Motifs changed TF binding or DNase peak
rs11642015 16:53,768,582 T/C 0.109 0.107 Intronic 0.817 0.401 100.0% 1.02 (0.77–1.35) 0.885 Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound, Motifs changed TF binding + DNase peak
rs1558902 16:53,769,662 A/T 0.105 0.106 Intronic 0.814 0.524 100.0% 0.99 (0.74–1.32) 0.942 Promoter histone marks, Enhancer histone marks, DNAse, Motifs changed TF binding or DNase peak
rs56094641 16:53,772,541 G/A 0.110 0.108 Intronic 0.999 0.427 100.0% 1.02 (0.77–1.35) 0.886 Promoter histone marks, Enhancer histone marks, DNAse, Motifs changed Motif hit
rs3751812 16:53,784,548 T/G 0.107 0.108 Intronic 0.999 0.561 99.8% 0.98 (0.74–1.31) 0.910 Enhancer histone marks, DNAse, Motifs changed TF binding + any motif + DNase peak
rs62033406 16:53,790,314 G/A 0.483 0.434 Intronic 0.465 0.215 99.9% 1.22 (1.02–1.46) 0.028 Enhancer histone marks, Motifs changed Motif hit
  1. Data from Haploreg (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php), and Regulome DB (https://regulome.stanford.edu/regulome-search/)
  2. ONFH, osteonecrosis of the femoral head; SNP, single nucleotide polymorphism; IS, ischemic stroke; MAF, minor allele frequency; HWE, Hardy–Weinberg equilibrium
  3. Bold indicate that p < 0.05 indicates statistical significance