FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

Table 2 The information about FTO SNPs and the association with ONFH susceptibility in allele model

SNPs ID	Chr: position	Alleles (minor/major)	Frequency (MAF)		Function	P value for HWE		Call rate	OR (95% CI)	P	Haploreg	Regulome DB
SNPs ID	Chr: position	Alleles (minor/major)	Case	Control	Function	Control	Case	Call rate	OR (95% CI)	P	Haploreg	Regulome DB
rs9930333	16:53,766,065	G/T	0.154	0.157	Intronic	0.610	0.105	99.8%	0.98 (0.77–1.25)	0.853	Enhancer histone marks, Motifs changed	TF binding or DNase peak
rs11642015	16:53,768,582	T/C	0.109	0.107	Intronic	0.817	0.401	100.0%	1.02 (0.77–1.35)	0.885	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound, Motifs changed	TF binding + DNase peak
rs1558902	16:53,769,662	A/T	0.105	0.106	Intronic	0.814	0.524	100.0%	0.99 (0.74–1.32)	0.942	Promoter histone marks, Enhancer histone marks, DNAse, Motifs changed	TF binding or DNase peak
rs56094641	16:53,772,541	G/A	0.110	0.108	Intronic	0.999	0.427	100.0%	1.02 (0.77–1.35)	0.886	Promoter histone marks, Enhancer histone marks, DNAse, Motifs changed	Motif hit
rs3751812	16:53,784,548	T/G	0.107	0.108	Intronic	0.999	0.561	99.8%	0.98 (0.74–1.31)	0.910	Enhancer histone marks, DNAse, Motifs changed	TF binding + any motif + DNase peak
rs62033406	16:53,790,314	G/A	0.483	0.434	Intronic	0.465	0.215	99.9%	1.22 (1.02–1.46)	0.028	Enhancer histone marks, Motifs changed	Motif hit

Data from Haploreg (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php), and Regulome DB (https://regulome.stanford.edu/regulome-search/)
ONFH, osteonecrosis of the femoral head; SNP, single nucleotide polymorphism; IS, ischemic stroke; MAF, minor allele frequency; HWE, Hardy–Weinberg equilibrium
Bold indicate that p < 0.05 indicates statistical significance

ISSN: 1755-8794