Table 3 Association between FTO polymorphisms and ONFH risk
SNP ID | Model | Genotype | Case | Control | OR (95% CI) | P value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
rs9930333 | Codominant | T/T | 362 (72.7%) | 352 (70.7%) | 1 | 0.210 | 1371.9 | 1406.2 |
G/T | 119 (23.9%) | 136 (27.3%) | 0.85 (0.64–1.14) | |||||
G/G | 17 (3.4%) | 10 (2%) | 1.66 (0.75–3.70) | |||||
Dominant | T/T | 362 (72.7%) | 352 (70.7%) | 1 | 0.490 | 1372.5 | 1401.9 | |
G/T-G/G | 136 (27.3%) | 146 (29.3%) | 0.91 (0.68–1.20) | |||||
Recessive | T/T-G/T | 481 (96.6%) | 488 (98%) | 1 | 0.170 | 1371.1 | 1400.5 | |
G/G | 17 (3.4%) | 10 (2%) | 1.74 (0.78–3.85) | |||||
Log-additive | – | – | – | 0.98 (0.77–1.25) | 0.860 | 1373 | 1402.4 | |
rs11642015 | Codominant | C/C | 397 (79.7%) | 397 (79.7%) | 1 | 0.890 | 1374.8 | 1409.1 |
T/C | 93 (18.7%) | 95 (19.1%) | 0.99 (0.72–1.37) | |||||
T/T | 8 (1.6%) | 6 (1.2%) | 1.30 (0.44–3.83) | |||||
Dominant | C/C | 397 (79.7%) | 397 (79.7%) | 1 | 0.940 | 1373 | 1402.4 | |
T/C-T/T | 101 (20.3%) | 101 (20.3%) | 1.01 (0.74–1.38) | |||||
Recessive | C/C-T/C | 490 (98.4%) | 492 (98.8%) | 1 | 0.620 | 1372.8 | 1402.2 | |
T/T | 8 (1.6%) | 6 (1.2%) | 1.31 (0.45–3.83) | |||||
Log-additive | – | – | – | 1.03 (0.78–1.36) | 0.840 | 1373 | 1402.4 | |
rs1558902 | Codominant | T/T | 400 (80.3%) | 398 (79.9%) | 1 | 0.970 | 1374.9 | 1409.3 |
A/T | 91 (18.3%) | 94 (18.9%) | 0.98 (0.71–1.35) | |||||
A/A | 7 (1.4%) | 6 (1.2%) | 1.13 (0.37–3.43) | |||||
Dominant | T/T | 400 (80.3%) | 398 (79.9%) | 1 | 0.940 | 1373 | 1402.4 | |
A/T-A/A | 98 (19.7%) | 100 (20.1%) | 0.99 (0.72–1.35) | |||||
Recessive | T/T-A/T | 491 (98.6%) | 492 (98.8%) | 1 | 0.820 | 1373 | 1402.4 | |
A/A | 7 (1.4%) | 6 (1.2%) | 1.14 (0.38–3.44) | |||||
Log-additive | – | – | – | 1.00 (0.75–1.33) | 0.990 | 1373 | 1402.4 | |
rs56094641 | Codominant | A/A | 396 (79.5%) | 396 (79.5%) | 1 | 0.890 | 1374.8 | 1409.1 |
G/A | 94 (18.9%) | 96 (19.3%) | 0.99 (0.72–1.37) | |||||
G/G | 8 (1.6%) | 6 (1.2%) | 1.30 (0.44–3.83) | |||||
Dominant | A/A | 396 (79.5%) | 396 (79.5%) | 1 | 0.950 | 1373 | 1402.4 | |
G/A-G/G | 102 (20.5%) | 102 (20.5%) | 1.01 (0.74–1.38) | |||||
Recessive | A/A-G/A | 490 (98.4%) | 492 (98.8%) | 1 | 0.620 | 1372.8 | 1402.2 | |
G/G | 8 (1.6%) | 6 (1.2%) | 1.31 (0.45–3.83) | |||||
Log-additive | – | – | – | 1.03 (0.77–1.36) | 0.850 | 1373 | 1402.4 | |
rs3751812 | Codominant | G/G | 397 (80%) | 396 (79.5%) | 1 | 0.960 | 1372.7 | 1407 |
G/T | 92 (18.6%) | 96 (19.3%) | 0.98 (0.71–1.35) | |||||
T/T | 7 (1.4%) | 6 (1.2%) | 1.14 (0.38–3.44) | |||||
Dominant | G/G | 397 (80%) | 396 (79.5%) | 1 | 0.920 | 1370.7 | 1400.1 | |
G/T-T/T | 99 (20%) | 102 (20.5%) | 0.98 (0.72–1.35) | |||||
Recessive | G/G-G/T | 489 (98.6%) | 492 (98.8%) | 1 | 0.810 | 1370.7 | 1400.1 | |
T/T | 7 (1.4%) | 6 (1.2%) | 1.14 (0.38–3.45) | |||||
Log-additive | – | – | – | 1.00 (0.75–1.32) | 0.980 | 1370.7 | 1400.2 | |
rs62033406 | Codominant | A/A | 126 (25.4%) | 164 (32.9%) | 1 | 0.011 | 1364.7 | 1399 |
G/A | 262 (52.7%) | 236 (47.4%) | 1.54 (1.14–2.07) | |||||
G/G | 109 (21.9%) | 98 (19.7%) | 1.52 (1.06–2.18) | |||||
Dominant | A/A | 126 (25.4%) | 164 (32.9%) | 1 | 0.003* | 1362.7 | 1392.1 | |
G/A-G/G | 371 (74.7%) | 334 (67.1%) | 1.53 (1.16–2.03) | |||||
Recessive | A/A-G/A | 388 (78.1%) | 400 (80.3%) | 1 | 0.350 | 1370.8 | 1400.2 | |
G/G | 109 (21.9%) | 98 (19.7%) | 1.16 (0.85–1.58) | |||||
Log-additive | – | – | – | 1.25 (1.05–1.50) | 0.014 | 1365.5 | 1394.9 |