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Table 3 Association between FTO polymorphisms and ONFH risk

From: FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

SNP ID Model Genotype Case Control OR (95% CI) P value AIC BIC
rs9930333 Codominant T/T 362 (72.7%) 352 (70.7%) 1 0.210 1371.9 1406.2
   G/T 119 (23.9%) 136 (27.3%) 0.85 (0.64–1.14)    
   G/G 17 (3.4%) 10 (2%) 1.66 (0.75–3.70)    
  Dominant T/T 362 (72.7%) 352 (70.7%) 1 0.490 1372.5 1401.9
   G/T-G/G 136 (27.3%) 146 (29.3%) 0.91 (0.68–1.20)    
  Recessive T/T-G/T 481 (96.6%) 488 (98%) 1 0.170 1371.1 1400.5
   G/G 17 (3.4%) 10 (2%) 1.74 (0.78–3.85)    
  Log-additive 0.98 (0.77–1.25) 0.860 1373 1402.4
rs11642015 Codominant C/C 397 (79.7%) 397 (79.7%) 1 0.890 1374.8 1409.1
   T/C 93 (18.7%) 95 (19.1%) 0.99 (0.72–1.37)    
   T/T 8 (1.6%) 6 (1.2%) 1.30 (0.44–3.83)    
  Dominant C/C 397 (79.7%) 397 (79.7%) 1 0.940 1373 1402.4
   T/C-T/T 101 (20.3%) 101 (20.3%) 1.01 (0.74–1.38)    
  Recessive C/C-T/C 490 (98.4%) 492 (98.8%) 1 0.620 1372.8 1402.2
   T/T 8 (1.6%) 6 (1.2%) 1.31 (0.45–3.83)    
  Log-additive 1.03 (0.78–1.36) 0.840 1373 1402.4
rs1558902 Codominant T/T 400 (80.3%) 398 (79.9%) 1 0.970 1374.9 1409.3
   A/T 91 (18.3%) 94 (18.9%) 0.98 (0.71–1.35)    
   A/A 7 (1.4%) 6 (1.2%) 1.13 (0.37–3.43)    
  Dominant T/T 400 (80.3%) 398 (79.9%) 1 0.940 1373 1402.4
   A/T-A/A 98 (19.7%) 100 (20.1%) 0.99 (0.72–1.35)    
  Recessive T/T-A/T 491 (98.6%) 492 (98.8%) 1 0.820 1373 1402.4
   A/A 7 (1.4%) 6 (1.2%) 1.14 (0.38–3.44)    
  Log-additive 1.00 (0.75–1.33) 0.990 1373 1402.4
rs56094641 Codominant A/A 396 (79.5%) 396 (79.5%) 1 0.890 1374.8 1409.1
   G/A 94 (18.9%) 96 (19.3%) 0.99 (0.72–1.37)    
   G/G 8 (1.6%) 6 (1.2%) 1.30 (0.44–3.83)    
  Dominant A/A 396 (79.5%) 396 (79.5%) 1 0.950 1373 1402.4
   G/A-G/G 102 (20.5%) 102 (20.5%) 1.01 (0.74–1.38)    
  Recessive A/A-G/A 490 (98.4%) 492 (98.8%) 1 0.620 1372.8 1402.2
   G/G 8 (1.6%) 6 (1.2%) 1.31 (0.45–3.83)    
  Log-additive 1.03 (0.77–1.36) 0.850 1373 1402.4
rs3751812 Codominant G/G 397 (80%) 396 (79.5%) 1 0.960 1372.7 1407
   G/T 92 (18.6%) 96 (19.3%) 0.98 (0.71–1.35)    
   T/T 7 (1.4%) 6 (1.2%) 1.14 (0.38–3.44)    
  Dominant G/G 397 (80%) 396 (79.5%) 1 0.920 1370.7 1400.1
   G/T-T/T 99 (20%) 102 (20.5%) 0.98 (0.72–1.35)    
  Recessive G/G-G/T 489 (98.6%) 492 (98.8%) 1 0.810 1370.7 1400.1
   T/T 7 (1.4%) 6 (1.2%) 1.14 (0.38–3.45)    
  Log-additive 1.00 (0.75–1.32) 0.980 1370.7 1400.2
rs62033406 Codominant A/A 126 (25.4%) 164 (32.9%) 1 0.011 1364.7 1399
   G/A 262 (52.7%) 236 (47.4%) 1.54 (1.14–2.07)    
   G/G 109 (21.9%) 98 (19.7%) 1.52 (1.06–2.18)    
  Dominant A/A 126 (25.4%) 164 (32.9%) 1 0.003* 1362.7 1392.1
   G/A-G/G 371 (74.7%) 334 (67.1%) 1.53 (1.16–2.03)    
  Recessive A/A-G/A 388 (78.1%) 400 (80.3%) 1 0.350 1370.8 1400.2
   G/G 109 (21.9%) 98 (19.7%) 1.16 (0.85–1.58)    
  Log-additive 1.25 (1.05–1.50) 0.014 1365.5 1394.9
  1. ONFH, osteonecrosis of the femoral head; SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; AIC, akaike information criterion; BIC, Bayesian information criterion
  2. p values were calculated using logistic regression analysis adjusted by gender, age, smoking and drinking
  3. Bold indicate that p < 0.05 means the data is statistically significant
  4. *p indicate that after Bonferroni correction (p < 0.05/6) means the data is statistically significant