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Table 4 Association between FTO polymorphisms and ONFH risk according to the stratification analysis

From: FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

SNP ID Model Genotype Case Control OR (95% CI) P value Control Case OR (95% CI) P value
Age, years    > 51       ≤ 51    
 rs62033406 Codominant A/A 64 (23.4%) 88 (37.3%) 1 7.00 × 10–4* 62 (27.7%) 76 (29%) 1 0.650
   G/A 143 (52.4%) 108 (45.8%) 2.00 (1.32–3.04)   119 (53.1%) 128 (48.9%) 1.15 (0.76–1.76)  
   G/G 66 (24.2%) 40 (16.9%) 2.39 (1.42–4.00)   43 (19.2%) 58 (22.1%) 0.95 (0.56–1.59)  
  Dominant A/A 64 (23.4%) 88 (37.3%) 1 2.00 × 10–4* 62 (27.7%) 76 (29%) 1 0.680
   G/A-G/G 209 (76.6%) 148 (62.7%) 2.11 (1.42–3.13)   162 (72.3%) 186 (71%) 1.09 (0.73–1.62)  
  Recessive A/A-G/A 207 (75.8%) 196 (83%) 1 0.051 181 (80.8%) 204 (77.9%) 1 0.510
   G/G 66 (24.2%) 40 (16.9%) 1.55 (0.99–2.42)   43 (19.2%) 58 (22.1%) 0.86 (0.55–1.35)  
  Log-additive 1.59 (1.22–2.05) 4.00 × 10–4* 0.99 (0.76–1.28) 0.910
Gender   Males      Females    
 rs9930333 Codominant T/T 206 (73.6%) 209 (67.2%) 1 0.030 156 (71.6%) 143 (76.5%) 1 0.650
   G/T 63 (22.5%) 96 (30.9%) 0.66 (0.45–0.96)   56 (25.7%) 40 (21.4%) 1.24 (0.77–1.99)  
   G/G 11 (3.9%) 6 (1.9%) 1.86 (0.67–5.16)   6 (2.8%) 4 (2.1%) 1.24 (0.34–4.56)  
  Dominant T/T 206 (73.6%) 209 (67.2%) 1 0.081 156 (71.6%) 143 (76.5%) 1 0.350
   G/T-G/G 74 (26.4%) 102 (32.8%) 0.73 (0.51–1.04)   62 (28.4%) 44 (23.5%) 1.24 (0.79–1.96)  
  Recessive T/T-G/T 269 (96.1%) 305 (98.1%) 1 0.150 212 (97.2%) 183 (97.9%) 1 0.810
   G/G 11 (3.9%) 6 (1.9%) 2.08 (0.75–5.76)   6 (2.8%) 4 (2.1%) 1.17 (0.32–4.29)  
  Log-additive 0.85 (0.62–1.16) 0.290 1.20 (0.80–1.79) 0.370
 rs62033406 Codominant A/A 74 (26.5%) 82 (26.4%) 1 0.820 52 (23.9%) 82 (43.9%) 1 1.00 × 10–4*
   G/A 150 (53.8%) 162 (52.1%) 1.09 (0.73–1.60)   112 (51.4%) 74 (39.6%) 2.42 (1.52–3.83)  
   G/G 55 (19.7%) 67 (21.5%) 0.96 (0.59–1.55)   54 (24.8%) 31 (16.6%) 2.75 (1.55–4.86)  
  Dominant A/A 74 (26.5%) 82 (26.4%) 1 0.810 52 (23.9%) 82 (43.9%) 1 < 0.0001*
   G/A-G/G 205 (73.5%) 229 (73.6%) 1.05 (0.72–1.52)   166 (76.2%) 105 (56.1%) 2.51 (1.63–3.87)  
  Recessive A/A-G/A 224 (80.3%) 244 (78.5%) 1 0.630 164 (75.2%) 156 (83.4%) 1 0.049
   G/G 55 (19.7%) 67 (21.5%) 0.90 (0.60–1.36)   54 (24.8%) 31 (16.6%) 1.65 (1.00–2.72)  
  Log-additive 0.98 (0.77–1.25) 0.890 1.74 (1.31–2.31) 1.00 × 10–4*
Smoking    Smokers     Non-smokers    
 rs62033406 Codominant A/A 44 (20.1%) 82 (30.5%) 1 0.020 82 (29.5%) 82 (35.8%) 1 0.290
   G/A 125 (57.1%) 134 (49.8%) 1.82 (1.16–2.84)   137 (49.3%) 102 (44.5%) 1.36 (0.91–2.03)  
   G/G 50 (22.8%) 53 (19.7%) 1.81 (1.06–3.09)   59 (21.2%) 45 (19.6%) 1.34 (0.81–2.22)  
  Dominant A/A 44 (20.1%) 82 (30.5%) 1 0.005* 82 (29.5%) 82 (35.8%) 1 0.120
   G/A-G/G 175 (79.9%) 187 (69.5%) 1.82 (1.19–2.78)   196 (70.5%) 147 (64.2%) 1.35 (0.93–1.98)  
  Recessive A/A-G/A 169 (77.2%) 216 (80.3%) 1 0.410 219 (78.8%) 184 (80.3%) 1 0.610
   G/G 50 (22.8%) 53 (19.7%) 1.20 (0.78–1.87)   59 (21.2%) 45 (19.6%) 1.12 (0.72–1.74)  
  Log-additive 1.36 (1.04–1.77) 0.023 1.18 (0.92–1.51) 0.190
Drinking    Drinkers     Non-drinkers    
 rs62033406 Codominant A/A 58 (21.9%) 81 (31.6%) 1 0.009 68 (29.3%) 83 (34.3%) 1 0.460
   G/A 150 (56.6%) 127 (49.6%) 1.91 (1.24–2.93)   112 (48.3%) 109 (45%) 1.27 (0.84–1.94)  
   G/G 57 (21.5%) 48 (18.8%) 1.84 (1.08–3.12)   52 (22.4%) 50 (20.7%) 1.29 (0.78–2.15)  
  Dominant A/A 58 (21.9%) 81 (31.6%) 1 0.002* 68 (29.3%) 83 (34.3%) 1 0.210
   G/A-G/G 207 (78.1%) 175 (68.4%) 1.89 (1.25–2.84)   164 (70.7%) 159 (65.7%) 1.28 (0.87–1.89)  
  Recessive A/A-G/A 208 (78.5%) 208 (81.2%) 1 0.430 180 (77.6%) 192 (79.3%) 1 0.610
   G/G 57 (21.5%) 48 (18.8%) 1.19 (0.77–1.86)   52 (22.4%) 50 (20.7%) 1.12 (0.72–1.74)  
  Log-additive 1.39 (1.07–1.81) 0.014 1.15 (0.89–1.48) 0.280
  1. ONFH, osteonecrosis of the femoral head; SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval
  2. p values were calculated using logistic regression analysis adjusted by gender, age, smoking and/or drinking
  3. Bold indicate that p < 0.05 means the data is statistically significant
  4. *p indicate that after Bonferroni correction (p < 0.05/6) means the data is statistically significant