Table 4 Association between FTO polymorphisms and ONFH risk according to the stratification analysis

Age, years

 > 51

 ≤ 51

 rs62033406

Codominant

A/A

64 (23.4%)

88 (37.3%)

1

7.00 × 10^–4*

62 (27.7%)

76 (29%)

1

G/A

143 (52.4%)

108 (45.8%)

2.00 (1.32–3.04)

119 (53.1%)

128 (48.9%)

1.15 (0.76–1.76)

G/G

66 (24.2%)

40 (16.9%)

2.39 (1.42–4.00)

43 (19.2%)

58 (22.1%)

0.95 (0.56–1.59)

Dominant

A/A

64 (23.4%)

88 (37.3%)

1

2.00 × 10^–4*

62 (27.7%)

76 (29%)

1

G/A-G/G

209 (76.6%)

148 (62.7%)

2.11 (1.42–3.13)

162 (72.3%)

186 (71%)

1.09 (0.73–1.62)

Recessive

A/A-G/A

207 (75.8%)

196 (83%)

1

0.051

181 (80.8%)

204 (77.9%)

1

G/G

66 (24.2%)

40 (16.9%)

1.55 (0.99–2.42)

43 (19.2%)

58 (22.1%)

0.86 (0.55–1.35)

Log-additive

–

–

–

1.59 (1.22–2.05)

4.00 × 10^–4*

–

–

0.99 (0.76–1.28)

Gender

Males

Females

 rs9930333

Codominant

T/T

206 (73.6%)

209 (67.2%)

1

0.030

156 (71.6%)

143 (76.5%)

1

G/T

63 (22.5%)

96 (30.9%)

0.66 (0.45–0.96)

56 (25.7%)

40 (21.4%)

1.24 (0.77–1.99)

G/G

11 (3.9%)

6 (1.9%)

1.86 (0.67–5.16)

6 (2.8%)

4 (2.1%)

1.24 (0.34–4.56)

Dominant

T/T

206 (73.6%)

209 (67.2%)

1

0.081

156 (71.6%)

143 (76.5%)

1

G/T-G/G

74 (26.4%)

102 (32.8%)

0.73 (0.51–1.04)

62 (28.4%)

44 (23.5%)

1.24 (0.79–1.96)

Recessive

T/T-G/T

269 (96.1%)

305 (98.1%)

1

0.150

212 (97.2%)

183 (97.9%)

1

G/G

11 (3.9%)

6 (1.9%)

2.08 (0.75–5.76)

6 (2.8%)

4 (2.1%)

1.17 (0.32–4.29)

Log-additive

–

–

–

0.85 (0.62–1.16)

0.290

–

–

1.20 (0.80–1.79)

 rs62033406

Codominant

A/A

74 (26.5%)

82 (26.4%)

1

0.820

52 (23.9%)

82 (43.9%)

1

G/A

150 (53.8%)

162 (52.1%)

1.09 (0.73–1.60)

112 (51.4%)

74 (39.6%)

2.42 (1.52–3.83)

G/G

55 (19.7%)

67 (21.5%)

0.96 (0.59–1.55)

54 (24.8%)

31 (16.6%)

2.75 (1.55–4.86)

Dominant

A/A

74 (26.5%)

82 (26.4%)

1

0.810

52 (23.9%)

82 (43.9%)

1

G/A-G/G

205 (73.5%)

229 (73.6%)

1.05 (0.72–1.52)

166 (76.2%)

105 (56.1%)

2.51 (1.63–3.87)

Recessive

A/A-G/A

224 (80.3%)

244 (78.5%)

1

0.630

164 (75.2%)

156 (83.4%)

1

G/G

55 (19.7%)

67 (21.5%)

0.90 (0.60–1.36)

54 (24.8%)

31 (16.6%)

1.65 (1.00–2.72)

Log-additive

–

–

–

0.98 (0.77–1.25)

0.890

–

–

1.74 (1.31–2.31)

Smoking

Smokers

Non-smokers

 rs62033406

Codominant

A/A

44 (20.1%)

82 (30.5%)

1

0.020

82 (29.5%)

82 (35.8%)

1

G/A

125 (57.1%)

134 (49.8%)

1.82 (1.16–2.84)

137 (49.3%)

102 (44.5%)

1.36 (0.91–2.03)

G/G

50 (22.8%)

53 (19.7%)

1.81 (1.06–3.09)

59 (21.2%)

45 (19.6%)

1.34 (0.81–2.22)

Dominant

A/A

44 (20.1%)

82 (30.5%)

1

0.005*

82 (29.5%)

82 (35.8%)

1

G/A-G/G

175 (79.9%)

187 (69.5%)

1.82 (1.19–2.78)

196 (70.5%)

147 (64.2%)

1.35 (0.93–1.98)

Recessive

A/A-G/A

169 (77.2%)

216 (80.3%)

1

0.410

219 (78.8%)

184 (80.3%)

1

G/G

50 (22.8%)

53 (19.7%)

1.20 (0.78–1.87)

59 (21.2%)

45 (19.6%)

1.12 (0.72–1.74)

Log-additive

–

–

–

1.36 (1.04–1.77)

0.023

–

–

1.18 (0.92–1.51)

Drinking

Drinkers

Non-drinkers

 rs62033406

Codominant

A/A

58 (21.9%)

81 (31.6%)

1

0.009

68 (29.3%)

83 (34.3%)

1

G/A

150 (56.6%)

127 (49.6%)

1.91 (1.24–2.93)

112 (48.3%)

109 (45%)

1.27 (0.84–1.94)

G/G

57 (21.5%)

48 (18.8%)

1.84 (1.08–3.12)

52 (22.4%)

50 (20.7%)

1.29 (0.78–2.15)

Dominant

A/A

58 (21.9%)

81 (31.6%)

1

0.002*

68 (29.3%)

83 (34.3%)

1

G/A-G/G

207 (78.1%)

175 (68.4%)

1.89 (1.25–2.84)

164 (70.7%)

159 (65.7%)

1.28 (0.87–1.89)

Recessive

A/A-G/A

208 (78.5%)

208 (81.2%)

1

0.430

180 (77.6%)

192 (79.3%)

1

G/G

57 (21.5%)

48 (18.8%)

1.19 (0.77–1.86)

52 (22.4%)

50 (20.7%)

1.12 (0.72–1.74)

Log-additive

–

–

–

1.39 (1.07–1.81)

0.014

–

–

1.15 (0.89–1.48)