FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

Table 5 False-positive report probability for the associations of FTO polymorphisms with ONFH risk

Group/ SNPs ID	Model	OR (95% CI)	Prior probability
Group/ SNPs ID	Model	OR (95% CI)	0.25	0.1	0.01	0.001	0.0001
Overall
rs62033406	Codominant	1.54 (1.14–2.07)	0.029	0.081	0.492	0.907	0.990
		1.52 (1.06–2.18)	0.127	0.304	0.828	0.980	0.998
	Dominant	1.53 (1.16–2.03)	0.021	0.061	0.416	0.878	0.986
	Log-additive	1.25 (1.05–1.50)	0.048	0.132	0.625	0.944	0.994
Age > 51 years
rs62033406	Codominant	2.00 (1.32–3.04)	0.007	0.021	0.189	0.701	0.959
		2.39 (1.42–4.00)	0.011	0.032	0.266	0.786	0.973
	Dominant	2.11 (1.42–3.13)	0.002	0.005	0.049	0.343	0.839
	Log-additive	1.59 (1.22–2.05)	0.003	0.009	0.095	0.515	0.914
Males
rs9930333	Codominant	0.66 (0.45–0.96)	0.157	0.358	0.860	0.984	0.998
Females
rs62033406	Codominant	2.42 (1.52–3.83)	0.002	0.007	0.071	0.437	0.886
		2.75 (1.55–4.86)	0.011	0.032	0.265	0.785	0.973
	Dominant	2.51 (1.63–3.87)	0.001	0.002	0.020	0.169	0.671
	Log-additive	1.74 (1.31–2.31)	0.003	0.007	0.077	0.455	0.893
Smokers			0.036	0.102	0.556	0.927	0.992
rs62033406	Codominant	1.82 (1.16–2.84)	0.122	0.294	0.821	0.979	0.998
		1.81 (1.06–3.09)	0.024	0.070	0.453	0.893	0.988
	Dominant	1.82 (1.19–2.78)	0.080	0.207	0.741	0.967	0.997
	Log-additive	1.36 (1.04–1.77)
Drinkers
rs62033406	Codominant	1.91 (1.24–2.93)	0.015	0.045	0.340	0.839	0.981
		1.84 (1.08–3.12)	0.102	0.255	0.790	0.974	0.997
	Dominant	1.89 (1.25–2.84)	0.011	0.031	0.263	0.782	0.973
	Log-additive	1.39 (1.07–1.81)	0.042	0.116	0.590	0.936	0.993

SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval
The level of false-positive report probability threshold was set at 0.2, and noteworthy findings are presented
Bold indicate that the level of false-positive report probability threshold < 0.2

ISSN: 1755-8794