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Table 5 False-positive report probability for the associations of FTO polymorphisms with ONFH risk

From: FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

Group/ SNPs ID Model OR (95% CI) Prior probability
0.25 0.1 0.01 0.001 0.0001
Overall        
 rs62033406 Codominant 1.54 (1.14–2.07) 0.029 0.081 0.492 0.907 0.990
  1.52 (1.06–2.18) 0.127 0.304 0.828 0.980 0.998
Dominant 1.53 (1.16–2.03) 0.021 0.061 0.416 0.878 0.986
Log-additive 1.25 (1.05–1.50) 0.048 0.132 0.625 0.944 0.994
Age > 51 years        
 rs62033406 Codominant 2.00 (1.32–3.04) 0.007 0.021 0.189 0.701 0.959
  2.39 (1.42–4.00) 0.011 0.032 0.266 0.786 0.973
Dominant 2.11 (1.42–3.13) 0.002 0.005 0.049 0.343 0.839
Log-additive 1.59 (1.22–2.05) 0.003 0.009 0.095 0.515 0.914
Males        
 rs9930333 Codominant 0.66 (0.45–0.96) 0.157 0.358 0.860 0.984 0.998
Females        
 rs62033406 Codominant 2.42 (1.52–3.83) 0.002 0.007 0.071 0.437 0.886
  2.75 (1.55–4.86) 0.011 0.032 0.265 0.785 0.973
Dominant 2.51 (1.63–3.87) 0.001 0.002 0.020 0.169 0.671
Log-additive 1.74 (1.31–2.31) 0.003 0.007 0.077 0.455 0.893
Smokers    0.036 0.102 0.556 0.927 0.992
 rs62033406 Codominant 1.82 (1.16–2.84) 0.122 0.294 0.821 0.979 0.998
  1.81 (1.06–3.09) 0.024 0.070 0.453 0.893 0.988
Dominant 1.82 (1.19–2.78) 0.080 0.207 0.741 0.967 0.997
Log-additive 1.36 (1.04–1.77)      
Drinkers        
 rs62033406 Codominant 1.91 (1.24–2.93) 0.015 0.045 0.340 0.839 0.981
  1.84 (1.08–3.12) 0.102 0.255 0.790 0.974 0.997
Dominant 1.89 (1.25–2.84) 0.011 0.031 0.263 0.782 0.973
Log-additive 1.39 (1.07–1.81) 0.042 0.116 0.590 0.936 0.993
  1. SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval
  2. The level of false-positive report probability threshold was set at 0.2, and noteworthy findings are presented
  3. Bold indicate that the level of false-positive report probability threshold < 0.2
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BMC Medical Genomics

ISSN: 1755-8794

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