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Table 6 MDR analysis for SNP–SNP interaction in FTO with ONFH susceptibility

From: FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population

Model Training Bal. Acc Testing Bal. Acc CVC OR (95% CI) p
rs62033406 0.5382 0.5382 10/10 1.45 (1.10–1.91) 0.008
rs56094641, rs62033406 0.5486 0.5321 8/10 1.52 (1.17–1.97) 0.0016
rs56094641, rs3751812, rs62033406 0.5522 0.5341 5/10 1.56 (1.20–2.02) 0.0008
rs9930333, rs56094641, rs3751812, rs62033406 0.5541 0.5351 7/10 1.59 (1.22–2.06) 0.0005
rs9930333, rs1558902, rs56094641, rs3751812, rs62033406 0.5558 0.5351 10/10 1.60 (1.24–2.08) 0.0004
rs9930333, rs11642015, rs1558902, rs56094641, rs3751812, rs62033406 0.5558 0.5351 10/10 1.60 (1.24–2.08) 0.0004
  1. MDR, multifactor dimensionality reduction; SNP, single nucleotide polymorphism; ONFH, osteonecrosis of the femoral head; Bal. Acc., balanced accuracy; CVC, cross–validation consistency; OR, odds ratio; CI, confidence interval
  2. p values were calculated using χ2 tests
  3. Bold indicate that p < 0.05 indicates statistical significance