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Table 1 List of all identified somatic mutations, including single-nucleotide variations, small insertions/deletions, copy number variations, and rearrangements

From: A lung adenocarcinoma patient with co-mutations of MET and EGFR exon20 insertion responded to crizotinib

Gene

Transcript

Nucleic acid changes

Amino acid changes

Functional area

Frequency/copy number

MET

NM_000245.2

c.3028_3028+1delGGinsTT

-

EX14-IVS14

44.4%

MLL3

NM_170606.2

c.7151G[2>1]

p.Q2385Rfs*67

EX37

38.4%

SERPINB4

NM_002974.2

c.964G>C

p.G322R

EX8

25.7%

CDC73

NM_024529.4

c.1590A>T

p.R530S

EX17

24.4%

EGFR

NM_005228.3

c.2311_2319dupAACCCCCAC

p.N771_H773dup

EX20

22.1%

TP53

NM_000546.5

c.548C>A

p.S183*

EX5

17.9%

TBX3

NM_016569.3

c.97GT

p.V33L

EX1

15.9%

RNF43

NM_017763.4

c.625A>G

p.I209V

EX6

14.3%

TP53

NM_000546.5

c.461G>T

p.G154V

EX5

12.3%

ATRX

NM_000489.3

c.5594G>A

p.R1865K

EX23

11.4%

LRP1B

NM_018557.2

c.11063T>C

p.L3688P

EX72

10.7%

NF1

NM_000267.3

c.6365-2A>C

IVS41

9.3%

BCOR

NM_001123385.1

c.2965A>T

p.S989C

EX4

9.1%

KDM5C

NM_004187.3

c.2953G>C

p.E985Q

EX19

8.6%

STAT3

NM_139276.2

c.1002C>A

p.D334E

EX10

8.4%

TBX3

NM_016569.3

c.1565C>A

p.P522H

EX7

8.1%

FANCD2

NM_033084.3

c.1767-1G>C

-

IVS19

5.0%

PALB2

NM_024675.3

c.129G>C

p.K43N

EX3

4.8%

TP73

NM_005427.3

c.806G>T

p.R269L

EX7

4.7%

OR4C6

NM_001004704.1

c.220G>C

p.V74L

EX1

4.5%

KDR

NM_002253.2

c.3625G>T

p.D1209Y

EX27

4.3%

MLL3

NM_170606.2

c.14292G>C

p.K4764N

EX55

3.9%

MLL

NM_001197104.1

c.3690G>C

p.E1230D

EX7

3.9%

ABL2

NM_007314.3

c.125C>T

p.T42I

EX1

3.7%

ARID1A

NM_006015.4

c.2369A>G

p.Q790R

EX7

3.5%

MLL3

NM_170606.2

c.14035C>T

p.P4679S

EX54

3.5%

U2AF1

NM_006758.2

c.235G>A

p.D79N

EX4

3.4%

CDKN2A

NM_000077.4

c.164G>T

p.G55V

EX2

3.3%

MLL3

NM_170606.2

c.7322G>T

p.G2441V

EX37

3.2%

NOTCH1

NM_017617.3

c.4501A>T

p.S1501C

EX25

3.0%

GRM3

NM_000840.2

c.1037A>T

p.H346L

EX3

2.6%

FAT1

NM_005245.3

c.7421G>T

p.S2474I

EX10

1.9%

AKT2

NM_001626.4

Amplification

All exon

2.2

MET

NM_000245.2

Amplification

All exon

2.2

CCND1

NM_053056.2

Amplification

All exon

1.7

  1. “–” means undetectable. Variant gene frequencies are defned as fractions of variant versus total sequencing read count expressed as percentages