Somatic targeted mutation profiling of colorectal cancer precursor lesions

BMC Medical Genomics

Table 3 Frequency of the most common altered genes in different groups of lesions

Gene	Adenoma		HP		SSL		Adjusted p value
Gene	n	(%)	n	(%)	n	(%)	Adjusted p value
APC	28	41.8	0	0.0	1	14.3	0.016^a
TP53	17	25.4	0	0.0	1	14.3	0.816^a
KRAS	15	22.4	2	12.5	0	0.0	> 0.999^a
BRAF	4	6.0	3	18.8	5	71.4	0.001^a
EGFR	6	9.0	1	6.3	0	0.0	> 0.999^a
FBXW7	6	9.0	0	0.0	0	0.0	0.752^a
GNAS	5	7.5	0	0.0	0	0.0	0.721^a
SMAD4	3	4.5	0	0.0	0	0.0	> 0.999^a
CTNNB1	3	4.5	0	0.0	0	0.0	> 0.999^a
PTEN	2	3.0	0	0.0	0	0.0	> 0.999^a
PIK3CA	1	1.5	0	0.0	1	14.3	> 0.999^a
MLH1	1	1.5	0	0.0	0	0.0	> 0.999^a
IDH2	0	0.0	0	0.0	1	14.3	> 0.999^a
HRAS	1	1.5	0	0.0	0	0.0	> 0.999^a
FGFR3	1	1.5	0	0.0	0	0.0	> 0.999^a
ATM	1	1.5	0	0.0	0	0.0	> 0.999^a

^aFisher's exact test; p values were adjusted for multiple comparisons with Bonferroni method

ISSN: 1755-8794