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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Effects and associated transcriptomic landscape changes of methamphetamine on immune cells

Fig. 2

Identification of differentially expressed genes (DEGs) in Jurkat cells with methamphetamine treatment. a Volcano plot showing DEGs (|Log2(foldchange)|> 0.5 and p < 0.05) between control (n = 3) and METH-treated cells (n = 3). Top 10 DEGs sorted by p value and genes of interest were shown in the plot. b Heatmap of DEGs (|Log2(foldchange)|> 0.5 and p < 0.05) between control (n = 3) and METH-treated cells (n = 3). c The protein–protein interaction (PPI) network of DEGs. The up-regulated genes are marked in red, while the down-regulated genes are marked in blue. The greater the difference in expression, the darker the color. The size of nodes represents the number of edges of the node; the larger the size, the greater the number of edges. d 10 hub genes were identified with the MCC algorithm, using cytoHubba. The score is indicated in red color. Darker color indicates a higher score

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