Table 2 Association of CYP11B1 polymorphisms and CHD risk
From: Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease
SNP | Model | Genotype | Case (N, %) | Control (N, %) | OR (95% CI) | p valuea |
|---|---|---|---|---|---|---|
rs4534 | Allele | C | 592 (58.50%) | 610 (60.04%) | 1.00 | |
T | 420 (41.50%) | 406 (39.96%) | 1.07(0.89–1.27) | 0.480 | ||
Codominant | CC | 165 (32.61%) | 181 (35.63%) | 1.00 | ||
Homozygote | TT | 79 (15.61%) | 79 (15.55%) | 1.11 (0.76 -1.62) | 0.582 | |
Heterozygote | TC | 262 (51.78%) | 248 (48.82%) | 1.16(0.88–1.53) | 0.279 | |
Dominant | CC | 165 (32.61%) | 181 (35.63%) | 1.00 | ||
TT + TC | 341 (67.39%) | 327 (64.37%) | 1.15 (0.89 -1.49) | 0.290 | ||
Recessive | TC + CC | 427 (84.39%) | 429 (84.45%) | 1.00 | ||
TT | 79 (15.61%) | 79 (15.55%) | 1.02(0.72–1.43) | 0.928 | ||
Additive | – | – | – | 1.08(0.90 -1.29) | 0.432 | |
rs5283 | Allele | G | 703 (69.33%) | 717 (70.715) | 1.00 | |
A | 311 (30.67%) | 297 (29.29%) | 1.07(0.88–1.29) | 0.497 | ||
Codominant | GG | 240 (47.33%) | 257 (50.69%) | 1.00 | ||
Homozygote | AA | 44 (8.68%) | 47 (9.27%) | 0.99 (0.63–1.56) | 0.978 | |
Heterozygote | AG | 223 (43.99) | 203 (40.03) | 1.18 (0.91–1.53) | 0.214 | |
Dominant | GG | 240 (47.33%) | 257 (50.69%) | 1.00 | ||
AA + AG | 267 (52.67%) | 250 (49.31%) | 1.14(0.89–1.46) | 0.286 | ||
Recessive | AG + GG | 463 (91.32%) | 460 (90.73%) | 1.00 | ||
AA | 44 (8.68%) | 47 (9.27%) | 0.92(0.60–1.42) | 0.708 | ||
Additive | – | – | – | 1.07 (0.88–1.29) | 0.510 | |
rs6410 | Allele | C | 741 (73.08%) | 712 (70.22%) | 1.00 | |
T | 273 (26.92%) | 306 (30.18%) | 0.86(0.71–1.04) | 0.117 | ||
Codominant | CC | 271 (53.45%) | 245 (48.13%) | 1.00 | ||
Homozygote | TT | 37 (7.30%) | 42 (8.25%) | 0.79 (0.49 -1.26) | 0.320 | |
Heterozygote | TC | 199 (39.25%) | 222 (43.62%) | 0.80(0.62–1.04) | 0.100 | |
Dominant | CC | 271 (53.45%) | 245 (48.13%) | 1.00 | ||
TT + TC | 236 (46.55%) | 264 (58.17%) | 0.80(0.63–1.03) | 0.080 | ||
Recessive | TC + CC | 470 (92.70%) | 467 (91.75%) | 1.00 | ||
TT | 37 (7.30%) | 42 (8.25%) | 0.87(0.55–1.37) | 0.540 | ||
Additive | – | – | – | 0.85 (0.70 -1.03) | 0.101 | |
rs4736312 | Allele | C | 850 (83.83%) | 853 (83.96%) | 1.00 | |
A | 164 (16.17%) | 163 (16.04%) | 1.01(0.80–1.28) | 0.936 | ||
Codominant | AA | 356 (70.22%) | 357 (20.28%) | 1.00 | ||
Homozygote | CC | 13 (2.56%) | 12 (2.36%) | 1.06(0.48–2.36) | 0.888 | |
Heterozygote | CA | 138 (27.22%) | 139 (27.36%) | 0.99(0.75–1.30) | 0.926 | |
Dominant | AA | 356 (70.22%) | 357 (70.28%) | 1.00 | ||
CC + CA | 151 (29.78%) | 151 (29.72%) | 0.99(0.76–1.30) | 0.957 | ||
Recessive | CA + AA | 494 (97.44%) | 496 (97.64%) | 1.00 | ||
CC | 13 (2.56%) | 12 (2.36%) | 1.06(0.48–2.36) | 0.880 | ||
Additive | – | – | – | 1.00(0.79–1.27) | 0.998 | |
rs5017238 | Allele | A | 838 (83.47%) | 850 (83.83%) | 1.00 | |
G | 166 (16.53%) | 164 (16.17%) | 1.03(0.81–1.30) | 0.827 | ||
Codominant | AA | 356 (70.92%) | 357 (70.41%) | 1.00 | ||
Homozygote | GG | 20 (3.98%) | 14 (2.76%) | 1.40(0.69–2.82) | 0.349 | |
Heterozygote | GA | 126(25.10%) | 136 (26.82%) | 0.92(0.69–1.22) | 0.573 | |
Dominant | AA | 356 (70.92%) | 357 (70.41%) | 1.00 | ||
GG + GA | 146 (29.08%) | 150 (29.59%) | 0.97(0.74–1.27) | 0.804 | ||
Recessive | GA + AA | 482 (96.02%) | 493 (97.24%) | 1.00 | ||
GG | 20 (3.98%) | 14 (2.76%) | 1.43(0.71–2.87) | 0.315 | ||
Additive | – | – | – | 1.02(0.81–1.28) | 0.898 | |
rs5301 | Allele | C | 841 (83.10%) | 853 (83.79%) | 1.00 | |
T | 171 (16.90%) | 165 (16.21%) | 1.05(0.83–1.33) | 0.676 | ||
Codominant | CC | 349 (68.97%) | 356 (69.94%) | 1.00 | ||
Homozygote | TT | 14 (2.77%) | 12 (2.36%) | 1.16(0.53–2.55) | 0.709 | |
Heterozygote | TC | 143 (28.26%) | 141 (27.70%) | 1.03(0.78–1.36) | 0.845 | |
Dominant | CC | 349 (68.97%) | 356 (69.94%) | 1.00 | ||
TT + TC | 157 (31.03%) | 153 (30.06%) | 1.04(0.79–1.36) | 0.783 | ||
Recessive | TC + CC | 492 (97.23%) | 497 (97.64%) | 1.00 | ||
TT | 14 (2.77%) | 12 (2.36%) | 1.15(0.53–2.52) | 0.723 | ||
Additive | – | 1.04(0.82–1.32) | 0.726 |