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Table 3 The association between CYP11B1 polymorphisms and CHD susceptibility stratified by age and gender

From: Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease

Age

SNP

Model

Genotype

 > 60 years

 ≤ 60 years

Case (N, %)

Control (N, %)

OR(95% CI)

p

Case (N, %)

Control (N, %)

OR(95% CI)

p

rs6410

Allele

C

401 (71.10%)

402 (70.77%)

1.00

 

340(75.56%)

310 (68.89%)

1.00

 
  

T

163 (28.90%)

166 (29.23%)

0.98(0.76–1.27)

0.904

110 (24.44%)

140 (31.11%)

0.72(0.53–0.96)

0.026

 

Codominant

CC

144 (51.06%)

142 (50.00%)

1.00

 

127 (56.45%)

103 (45.78%)

1.00

 
  

TT

25 (8.87%)

24 (8.45%)

1.01(0.55–1.87)

0.970

12 (5.33%)

18 (8.00%)

0.54(0.25–1.18)

0.122

  

TC

113 (40.07%)

118 (41.55%)

0.89(0.63–1.27)

0.525

86 (38.22%)

104 (46.22%)

0.67(0.45–0.99)

0.042

 

Dominant

CC

144 (51.06%)

142 (50.00%)

1.00

 

127 (56.45%)

103 (45.78%)

1.00

 
  

TT + TC

138(48.94%)

130 (50.00%)

0.91(0.65–1.27)

0.589

98(43.55%)

122 (54.22%)

0.65(0.45–0.94)

0.023

 

Recessive

TC + CC

257 (91.13%)

260 (91.55%)

1.00

 

213 (94.67%)

207 (92.00%)

1.00

 
  

TT

25 (8.87%)

24 (8.45%)

1.07(0.59–1.93)

0.836

12 (5.33%)

18 (8.00%)

0.65(0.30–1.38)

0.258

 

Additive

0.96(0.74–1.24)

0.743

/

/

0.70(0.52–0.95)

0.022

rs4534

Allele

C

341 (60.68%)

337 (59.33%)

1.00

 

251 (55.78%)

273 (60.94%)

1.00

 
  

T

221 (39.32%)

231 (40.67%)

0.95(0.75–1.20)

0.644

199 (44.22%)

175 (39.06%)

1.24(0.95–1.61)

0.117

 

Codominant

CC

104 (37.01%)

95 (33.45%)

1.00

 

61 (27.11%)

86 (38.39%)

1.00

 
  

TT

44 (15.66%)

42 (14.79%)

0.99(0.59–1.65)

0.956

35 (15.56%)

37 (16.52%)

1.33(0.76–2.35)

0.321

  

TC

133 (47.33%)

147 (51.76%)

0.82(0.56–1.18)

0.279

129 (57.33%)

101 (45.09%)

1.80(1.19–2.74)

0.006

 

Dominant

CC

104 (37.01%)

95 (33.45%)

1.00

 

61 (27.11%)

86 (38.39%)

1.00

 
  

TT + TC

177 (62.99%)

189 (66.55%)

0.85(0.60–1.21)

0.372

164 (72.89%)

138 (61.61%)

1.68(1.13–2.50)

0.011

 

Recessive

TC + CC

237 (84.34%)

233 (85.21%)

1.00

 

190 (84.44%)

187 (83.48%)

1.00

 
  

TT

44 (15.66%)

42 (14.79%)

1.11(0.70–1.77)

0.658

35 (15.56%)

37 (16.52%)

0.93(0.56–1.54)

0.780

 

Additive

0.95(0.74–1.22)

0.694

/

/

1.25(0.95–1.65)

0.108

Gender

Gene SNP

Model

Genotype

Male

Female

Case (N, %)

Control (N, %)

OR(95% CI)

p

Case (N, %)

Control (N, %)

OR(95% CI)

p

rs5283

Allele

G

464 (69.46%)

458 (68.77%)

1.00

 

374 (68.00%)

259 (74.43%)

1.00

 
  

A

204 (30.54%)

208 (31.23%)

0.97(0.77–1.22)

0.784

176 (32.00%)

89 (25.57%)

1.37(1.01–1.85)

0.040

 

Codominant

GG

163 (48.80%)

157 (47.15%)

1.00

 

118 (42.91%)

100 (57.47%)

1.00

 
 

Homozygote

AA

33 (9.88%)

32 (9.61%)

0.99(0.58–1.69)

0.977

19 (6.91%)

15 (8.62%)

1.08(0.52–2.24)

0.838

 

Heterozygote

AG

138 (41.32%)

144 (43.24%)

0.92(0.67–1.27)

0.629

138 (50.18%)

59 (33.91%)

1.98(1.32–2.97)

0.001

 

Dominant

GG

163 (48.80%)

157 (47.15%)

1.00

 

118 (42.91%)

100 (57.47%)

1.00

 
  

AA + AG

171(51.20%)

176 (52.85%)

0.94(0.69–1.27)

0.672

157 (57.09%)

74 (42.53%)

1.80(1.23–2.64)

0.003

 

Recessive

AG + GG

301 (90.12%)

301 (90.39%)

1.00

 

256 (93.09%)

159 (91.38%)

1.00

 
  

AA

33 (9.88%)

32 (9.61%)

1.03(0.62–1.72)

0.912

19 (6.91%)

15 (8.62%)

0.79(0.39–1.60)

0.514

 

Additive

0.97(0.77–1.22)

0.786

/

/

1.40(1.03–1.91)

0.034

rs6410

Allele

C

478 (71.56%)

478 (71.34%)

1.00

 

413 (75.09%)

234 (67.24%)

1.00

 
  

T

190 (28.44%)

192 (28.66%)

0.99(0.78–1.26)

0.931

137 (24.91%)

114 (32.76%)

0.68(0.51–0.92)

0.011

 

Codominant

CC

176 (52.70%)

169 (50.44%)

1.00

 

152 (55.27%)

76 (43.68%)

1.00

 
 

H omozygote

TT

32 (9.58%)

26 (7.76%)

1.17(0.67–2.06)

0.573

14 (5.09%)

16 (9.20%)

0.44(0.20–0.95)

0.036

 

Heterozygote

TC

126 (37.72%)

140 (41.20%)

0.86(0.62–1.19)

0.357

109 (39.64%)

82 (47.12%)

0.67(0.45–0.99)

0.044

 

Dominant

CC

176 (52.70%)

169 (50.44%)

1.00

 

152 (55.27%)

76 (43.68%)

1.00

 
  

TT + TC

158 (47.30%)

166 (49.56%)

0.91(0.67–1.23)

0.539

123 (44.73%)

98 (56.32%)

0.63(0.43–0.92)

0.017

 

Recessive

TC + CC

302 (90.42%)

309 (92.24%)

1.00

 

261 (94.91%)

158 (90.80%)

1.00

 
  

TT

32 (9.58%)

26 (7.76%)

1.25(0.73–2.16)

0.412

14 (5.09%)

16 (9.20%)

0.53(0.25–1.12)

0.096

 

Additive

0.99(0.78–1.25)

0.907

/

/

0.66(0.49–0.90)

0.009

  1. SNP single nucleotide polymorphism; OR odds ratio; 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustment for age and gender
  3. Bold values indicate statistical significance (p < 0.05)