From: Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease
Age | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
SNP | Model | Genotype | > 60 years | ≤ 60 years | ||||||
Case (N, %) | Control (N, %) | OR(95% CI) | p | Case (N, %) | Control (N, %) | OR(95% CI) | p | |||
rs6410 | Allele | C | 401 (71.10%) | 402 (70.77%) | 1.00 | 340(75.56%) | 310 (68.89%) | 1.00 | ||
T | 163 (28.90%) | 166 (29.23%) | 0.98(0.76–1.27) | 0.904 | 110 (24.44%) | 140 (31.11%) | 0.72(0.53–0.96) | 0.026 | ||
Codominant | CC | 144 (51.06%) | 142 (50.00%) | 1.00 | 127 (56.45%) | 103 (45.78%) | 1.00 | |||
TT | 25 (8.87%) | 24 (8.45%) | 1.01(0.55–1.87) | 0.970 | 12 (5.33%) | 18 (8.00%) | 0.54(0.25–1.18) | 0.122 | ||
TC | 113 (40.07%) | 118 (41.55%) | 0.89(0.63–1.27) | 0.525 | 86 (38.22%) | 104 (46.22%) | 0.67(0.45–0.99) | 0.042 | ||
Dominant | CC | 144 (51.06%) | 142 (50.00%) | 1.00 | 127 (56.45%) | 103 (45.78%) | 1.00 | |||
TT + TC | 138(48.94%) | 130 (50.00%) | 0.91(0.65–1.27) | 0.589 | 98(43.55%) | 122 (54.22%) | 0.65(0.45–0.94) | 0.023 | ||
Recessive | TC + CC | 257 (91.13%) | 260 (91.55%) | 1.00 | 213 (94.67%) | 207 (92.00%) | 1.00 | |||
TT | 25 (8.87%) | 24 (8.45%) | 1.07(0.59–1.93) | 0.836 | 12 (5.33%) | 18 (8.00%) | 0.65(0.30–1.38) | 0.258 | ||
Additive | – | – | – | 0.96(0.74–1.24) | 0.743 | / | / | 0.70(0.52–0.95) | 0.022 | |
rs4534 | Allele | C | 341 (60.68%) | 337 (59.33%) | 1.00 | 251 (55.78%) | 273 (60.94%) | 1.00 | ||
T | 221 (39.32%) | 231 (40.67%) | 0.95(0.75–1.20) | 0.644 | 199 (44.22%) | 175 (39.06%) | 1.24(0.95–1.61) | 0.117 | ||
Codominant | CC | 104 (37.01%) | 95 (33.45%) | 1.00 | 61 (27.11%) | 86 (38.39%) | 1.00 | |||
TT | 44 (15.66%) | 42 (14.79%) | 0.99(0.59–1.65) | 0.956 | 35 (15.56%) | 37 (16.52%) | 1.33(0.76–2.35) | 0.321 | ||
TC | 133 (47.33%) | 147 (51.76%) | 0.82(0.56–1.18) | 0.279 | 129 (57.33%) | 101 (45.09%) | 1.80(1.19–2.74) | 0.006 | ||
Dominant | CC | 104 (37.01%) | 95 (33.45%) | 1.00 | 61 (27.11%) | 86 (38.39%) | 1.00 | |||
TT + TC | 177 (62.99%) | 189 (66.55%) | 0.85(0.60–1.21) | 0.372 | 164 (72.89%) | 138 (61.61%) | 1.68(1.13–2.50) | 0.011 | ||
Recessive | TC + CC | 237 (84.34%) | 233 (85.21%) | 1.00 | 190 (84.44%) | 187 (83.48%) | 1.00 | |||
TT | 44 (15.66%) | 42 (14.79%) | 1.11(0.70–1.77) | 0.658 | 35 (15.56%) | 37 (16.52%) | 0.93(0.56–1.54) | 0.780 | ||
Additive | – | – | – | 0.95(0.74–1.22) | 0.694 | / | / | 1.25(0.95–1.65) | 0.108 |
Gender | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Gene SNP | Model | Genotype | Male | Female | ||||||
Case (N, %) | Control (N, %) | OR(95% CI) | p | Case (N, %) | Control (N, %) | OR(95% CI) | p | |||
rs5283 | Allele | G | 464 (69.46%) | 458 (68.77%) | 1.00 | 374 (68.00%) | 259 (74.43%) | 1.00 | ||
A | 204 (30.54%) | 208 (31.23%) | 0.97(0.77–1.22) | 0.784 | 176 (32.00%) | 89 (25.57%) | 1.37(1.01–1.85) | 0.040 | ||
Codominant | GG | 163 (48.80%) | 157 (47.15%) | 1.00 | 118 (42.91%) | 100 (57.47%) | 1.00 | |||
Homozygote | AA | 33 (9.88%) | 32 (9.61%) | 0.99(0.58–1.69) | 0.977 | 19 (6.91%) | 15 (8.62%) | 1.08(0.52–2.24) | 0.838 | |
Heterozygote | AG | 138 (41.32%) | 144 (43.24%) | 0.92(0.67–1.27) | 0.629 | 138 (50.18%) | 59 (33.91%) | 1.98(1.32–2.97) | 0.001 | |
Dominant | GG | 163 (48.80%) | 157 (47.15%) | 1.00 | 118 (42.91%) | 100 (57.47%) | 1.00 | |||
AA + AG | 171(51.20%) | 176 (52.85%) | 0.94(0.69–1.27) | 0.672 | 157 (57.09%) | 74 (42.53%) | 1.80(1.23–2.64) | 0.003 | ||
Recessive | AG + GG | 301 (90.12%) | 301 (90.39%) | 1.00 | 256 (93.09%) | 159 (91.38%) | 1.00 | |||
AA | 33 (9.88%) | 32 (9.61%) | 1.03(0.62–1.72) | 0.912 | 19 (6.91%) | 15 (8.62%) | 0.79(0.39–1.60) | 0.514 | ||
Additive | – | – | – | 0.97(0.77–1.22) | 0.786 | / | / | 1.40(1.03–1.91) | 0.034 | |
rs6410 | Allele | C | 478 (71.56%) | 478 (71.34%) | 1.00 | 413 (75.09%) | 234 (67.24%) | 1.00 | ||
T | 190 (28.44%) | 192 (28.66%) | 0.99(0.78–1.26) | 0.931 | 137 (24.91%) | 114 (32.76%) | 0.68(0.51–0.92) | 0.011 | ||
Codominant | CC | 176 (52.70%) | 169 (50.44%) | 1.00 | 152 (55.27%) | 76 (43.68%) | 1.00 | |||
H omozygote | TT | 32 (9.58%) | 26 (7.76%) | 1.17(0.67–2.06) | 0.573 | 14 (5.09%) | 16 (9.20%) | 0.44(0.20–0.95) | 0.036 | |
Heterozygote | TC | 126 (37.72%) | 140 (41.20%) | 0.86(0.62–1.19) | 0.357 | 109 (39.64%) | 82 (47.12%) | 0.67(0.45–0.99) | 0.044 | |
Dominant | CC | 176 (52.70%) | 169 (50.44%) | 1.00 | 152 (55.27%) | 76 (43.68%) | 1.00 | |||
TT + TC | 158 (47.30%) | 166 (49.56%) | 0.91(0.67–1.23) | 0.539 | 123 (44.73%) | 98 (56.32%) | 0.63(0.43–0.92) | 0.017 | ||
Recessive | TC + CC | 302 (90.42%) | 309 (92.24%) | 1.00 | 261 (94.91%) | 158 (90.80%) | 1.00 | |||
TT | 32 (9.58%) | 26 (7.76%) | 1.25(0.73–2.16) | 0.412 | 14 (5.09%) | 16 (9.20%) | 0.53(0.25–1.12) | 0.096 | ||
Additive | – | – | – | 0.99(0.78–1.25) | 0.907 | / | / | 0.66(0.49–0.90) | 0.009 |