Table 4 Associations of CYP11B1 polymorphisms and CHD risk stratified by diabetes and hypertension
From: Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease
SNP | Model | Genotype | Diabetes | Hypertension | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case (N, %) | Control (N, %) | OR(95% CI) | p | Case (N, %) | Control (N, %) | OR(95% CI) | p | |||
rs5283 | Allele | G | 187 (63.61%) | 516 (71.67%) | 1.00 | 439 (69.24%) | 264 (69.47%) | 1.00 | ||
A | 107 (36.39%) | 204(28.33%) | 1.45(1.09–1.93) | 0.012 | 195 (30.76%) | 116 (30.53%) | 1.01(0.77–1.33) | 0.939 | ||
Codominant | GG | 55 (37.42%) | 185 (51.39%) | 1.00 | 150 (47.32%) | 90 (47.37%) | 1.00 | |||
AA | 15 (10.20%) | 29 (8.06%) | 1.73(0.86–3.46) | 0.123 | 28 (8.83%) | 16 (8.42%) | 1.06(0.54–2.08) | 0.868 | ||
AG | 77 (52.38%) | 146 (40.55%) | 1.79(1.19–2.70) | 0.006 | 139 (43.85%) | 84 (44.21%) | 0.98(0.67–1.44) | 0.921 | ||
Dominant | GG | 55 (37.42%) | 185 (51.39%) | 1.00 | 150 (47.32%) | 90 (47.37%) | 1.00 | |||
AA + AG | 92 (62.58%) | 175 (48.61%) | 1.78(1.20–2.64) | 0.004 | 167 (52.68%) | 100 (52.63%) | 0.99(0.69–1.4) | 0.972 | ||
Recessive | AG + GG | 132 (89.08%) | 331 (91.94%) | 1.00 | 289 (91.17%) | 174 (91.58%) | 1.00 | |||
AA | 15 (10.20%) | 29 (8.06%) | 1.29(0.67–2.49) | 0.450 | 28 (8.83%) | 16 (8.42%) | 1.07(0.56–2.05) | 0.842 | ||
Additive | – | – | – | 1.47(1.09–1.98) | 0.011 | / | / | 1.01(0.76–1.34) | 0.952 | |
rs4534 | Allele | C | 186 (63.70%) | 406 (56.39%) | 1.00 | 356 (56.33%) | 236 (62.11%) | 1.00 | ||
T | 106 (36.30%) | 314 (43.61%) | 0.74(0.56–0.98) | 0.032 | 276 (43.67%) | 144 (37.89%) | 1.27(0.98–1.65) | 0.071 | ||
Codominant | CC | 57 (39.04%) | 108 (30.00%) | 1.00 | 98 (31.01%) | 67 (35.26%) | 1.00 | |||
Homozygote | TT | 17 (11.64%) | 62 (17.22%) | 0.53(0.28–0.99) | 0.048 | 58 (18.35%) | 21 (11.05%) | 1.97(1.08–3.59) | 0.026 | |
Heterozygote | TC | 72 (49.32%) | 190 (52.78%) | 0.74(0.48–1.13) | 0.157 | 160 (50.63%) | 102 (53.69%) | 1.12(0.75–1.68) | 0.581 | |
Dominant | CC | 57 (39.04%) | 108 (30.00%) | 1.00 | 98 (31.01%) | 67 (35.26%) | 1.00 | |||
TT + TC | 89 (60.96%) | 252 (70.00%) | 0.69(0.46–1.03) | 0.068 | 218 (68.99%) | 123 (64.74%) | 1.26(0.86–1.87) | 0.238 | ||
Recessive | TC + CC | 129 (88.36%) | 298 (82.78%) | 1.00 | 258 (81.65%) | 169 (88.95%) | 1.00 | |||
TT | 17 (11.64%) | 62 (17.22%) | 0.64(0.36–1.14) | 0.126 | 58 (18.35%) | 21 (11.05%) | 1.84(1.07–3.16) | 0.028 | ||
Additive | – | – | – | 0.73(0.54–0.98) | 0.036 | / | / | 1.33(1.01–1.75) | 0.044 | |