Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease

BMC Medical Genomics

Table 6 MDR analysis of SNP-SNP interactions

Model	Training Bal. Acc	Testing Bal. Acc	CVC	OR (95% CI)	p
rs6410	0.527	0.518	7/10	1.24 (0.97–1.58)	0.091
rs5017238,rs6410	0.542	0.492	7/10	1.39 (1.08–1.79)	0.009
rs5017238,rs6410,rs4534	0.550	0.500	7/10	1.46 (1.14–1.87)	0.003
rs5017238,rs5301,rs5283,rs4534	0.554	0.503	6/10	1.51 (1.18–1.93)	0.0011
rs4736312,rs5017238,rs5301,rs5283,rs4534	0.554	0.503	6/10	1.51 (1.18–1.93)	0.0011
rs4736312,rs5017238,rs5301,rs5283,rs6410,rs4534	0.554	0.497	10/10	1.51 (1.18–1.93)	0.0011

MDR multifactor dimensionality reduction; Bal. Acc. balanced accuracy; CVC cross–validation consistency; OR, odds ratio; CI, confidence interval
p < 0.05 indicates statistical significance, which was indicated in bold

ISSN: 1755-8794