Table 2 Relationships among symptoms across seven organ systems in HCTD patients. Shown are results of chi-square (χ2) tests comparing symptoms among seven organ systems in patients with heritable connective tissue disorders (HCTDs). Systems evidenced to be independent, based on unadjusted p ≥ 0.10, were subsequently included in LCA models. Specific clinical features and percentages reflecting the overall system with symptoms present can be found in Table 1. Included are Benjamini–Hochberg adjusted p values. Expected counts were rounded to the nearest whole number. Abbreviations: obs = observed, exp = expected, OR = odds ratio, CI = confidence interval
From: Clinical genetics evaluation and testing of connective tissue disorders: a cross-sectional study
Symptoms in both systems | χ2 | OR (95%CI) | p value | p valueadjusted | |
|---|---|---|---|---|---|
Skeletal | |||||
Connective Tissue | obs = 47; exp = 50 | 1.58 | 1.52 (0.79, 2.91) | 0.21 | 0.58 |
Skin | obs = 51; exp = 49 | 0.74 | 1.33 (0.69, 2.55) | 0.39 | 0.70 |
Eye | obs = 21; exp = 20 | 0.05 | 1.32 (0.69, 2.53) | 0.82 | 1.00 |
Nervous | obs = 30; exp = 29 | 0.16 | 1.62 (0.84, 3.12) | 0.69 | 0.97 |
Gastrointestinal | obs = 22; exp = 23 | 0.02 | 1.51 (0.79, 2.89) | 0.90 | 1.00 |
Cardiovascular | obs = 19; exp = 16 | 1.31 | 1.40 (0.73, 2.68) | 0.25 | 0.58 |
Connective tissue | |||||
Skin | obs = 78; exp = 75 | 5.27 | 2.18 (1.12, 4.24) | 0.02 | 0.42 |
Eye | obs = 34; exp = 30 | 3.62 | 1.89 (0.98, 3.66) | 0.06 | 0.58 |
Nervous | obs = 46; exp = 44 | 1.41 | 1.45 (0.77, 2.85) | 0.23 | 0.58 |
Gastrointestinal | obs = 38; exp = 35 | 2.69 | 1.73 (0.90, 3.33) | 0.10 | 0.86 |
Cardiovascular | obs = 23; exp = 24 | 0.32 | 1.21 (0.63, 2.31) | 0.57 | 0.86 |
Skin | |||||
Eye | obs = 32; exp = 30 | 0.72 | 1.32 (0.69, 2.53) | 0.40 | 0.70 |
Nervous | obs = 46; exp = 43 | 2.08 | 1.62 (0.84, 3.11) | 0.15 | 0.58 |
Gastrointestinal | obs = 37; exp = 34 | 1.53 | 1.51 (0.79, 2.89) | 0.22 | 0.58 |
Cardiovascular | obs = 22; exp = 24 | 1.03 | 1.40 (0.73, 2.68) | 0.31 | 0.65 |
Eye | |||||
Nervous | obs = 21; exp = 18 | 1.58 | 1.52 (0.79, 2.92) | 0.21 | 0.58 |
Gastrointestinal | obs = 14; exp = 14 | 0.00 | NA | 1.00 | 1.00 |
Cardiovascular | obs = 10; exp = 10 | 2.70 × 10–31 | 1.00 (0.52, 1.91) | 1.00 | 1.00 |
Nervous System | |||||
Gastrointestinal | obs = 22; exp = 20 | 0.38 | 1.22 (0.64, 2.34) | 0.54 | 0.86 |
Cardiovascular | obs = 13; exp = 14 | 0.05 | 1.08 (0.56, 2.06) | 0.82 | 1.00 |
Gastrointestinal | |||||
Cardiovascular | obs = 11; exp = 11 | 2.91 × 10–31 | 1.00 (0.52, 1.91) | 1.00 | 1.00 |