Table 5 Direct comparisons of symptoms and demographics between latent class. Reported are Fisher’s exact test results for differences in the number of patients with symptoms observed in evaluated organ systems between each of the latent classes (see Fig. 2 for details on latent class analysis results). Unadjusted and Benjamini–Hochberg adjusted p values are provided
From: Clinical genetics evaluation and testing of connective tissue disorders: a cross-sectional study
Organ System | Latent Class Comparison | p value | p valueadjusted |
|---|---|---|---|
Skeletal | Class 1 versus Class 2 | 8.60 × 10–5 | 4.13 × 10–4 |
Class 1 versus Class 3 | 5.62 × 10–4 | 1.35 × 10–3 | |
Class 2 versus Class 3 | 0.15 | 0.22 | |
Connective Tissue | Class 1 versus Class 2 | 9.27 × 10–4 | 1.85 × 10–3 |
Class 1 versus Class 3 | 1.00 | 1.00 | |
Class 2 versus Class 3 | 3.13 × 10–5 | 1.88 × 10–4 | |
Skin | Class 1 versus Class 2 | 0.69 | 0.75 |
Class 1 versus Class 3 | 0.37 | 0.46 | |
Class 2 versus Class 3 | 0.04 | 0.07 | |
Nervous | Class 1 versus Class 2 | 0.49 | 0.58 |
Class 1 versus Class 3 | 1.03 × 10–6 | 8.20 × 10–6 | |
Class 2 versus Class 3 | 1.78 × 10–8 | 2.13 × 10–7 | |
Gastrointestinal | Class 1 versus Class 2 | 2.97 × 10–4 | 8.90 × 10–4 |
Class 1 versus Class 3 | 0.58 | 0.66 | |
Class 2 versus Class 3 | 1.52 × 10–4 | 5.23 × 10–4 | |
Cardiovascular | Class 1 versus Class 2 | 9.27 × 10–4 | 1.85 × 10–3 |
Class 1 versus Class 3 | 0.02 | 0.03 | |
Class 2 versus Class 3 | 0.08 | 0.13 | |
Gender | Class 1 versus Class 2 | 0.16 | 0.22 |
Class 1 versus Class 3 | 0.21 | 0.28 | |
Class 2 versus Class 3 | 3.63 × 10–4 | 9.69 × 10–4 | |
Age | Class 1 versus Class 2 | 1.35 × 10–4 | 5.23 × 10–4 |
Class 1 versus Class 3 | 9.22 × 10–8 | 2.21 × 10–8 | |
Class 2 versus Class 3 | 0.97 | 1.00 |