Table 2 Genotype and allele frequency of IKZF1 and CDKN2A gene polymorphisms and the association with childhood ALL

IKZF1 rs4132601 T > G

Genotype

TT

25 (50%)

24 (48%)

–

1.0

–

–

TG

16 (32%)

20 (40%)

0.549

0.76

0.32

1.82

GG

9 (18%)

6 (12%)

0.543

1.44

0.44

4.66

Dominant model

TG + GG

25 (50%)

26 (52%)

0.84

0.92

0.42

2.02

Recessive model

TT + TG

41 (82%)

44 (88%)

0.4

0.62

0.20

1.90

Allele

T

66 (66%)

68 (68%)

–

1.0

–

–

G

34 (34%)

32 (32%)

0.764

1.09

0.60

1.97

CDKN2A rs3731217 A > C

Genotype

AA

48 (96%)

49 (98%)

–

1.0

–

–

AC

2 (4%)

1 (2%)

0.565

2.04

0.17

23.26

CC

0 (0%)

0 (0%)

–

–

–

–

Allele

A

98 (98%)

99 (99%)

–

1.0

–

–

C

2 (2%)

1 (1%)

0.568

2.02

0.18

22.64

CDKN2A rs3731249 C > T

Genotype

CC

41 (82%)

49 (98%)

–

1.0

–

–

CT

8 (16%)

1 (2%)

0.037

9.56

1.14

79.64

TT

1 (2%)

0 (0%)

–

–

–

–

Dominant model

CT + TT

9 (18%)

1 (2%)

0.004

10.76

1.31

88.46

Recessive model

CC + CT

49 (98%)

50 (100%)

0.24

0.00

0.00

NA

Allele

C

90 (90%)

99 (99%)

–

1.0

–

–

T

10 (10%)

1 (1%)

0.024

11.00

1.38

87.64