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Table 2 Top 10 skin proteins with significant down-regulation in chemical warfare victims

From: Proteomics analysis of chronic skin injuries caused by mustard gas

Accession ID P-value Fold change Gene name Protein name Pathogenesis pathway
P20718 2.5E−03 0.31 GZMH Granzyme H OS = Homo sapiens OX = 9606 GN = GZMH PE = 1 SV = 1 Due to the fact that granzyme H is primarily expressed in CD3 − CD56 + NK (natural killer) cells of the immune system, decreased expression of this protein is associated with impaired induction of target cell death in pathogen-infected cells
P69891 9.3E−03 0.54 HBG1 Hemoglobin subunit gamma-1 OS = Homo sapiens OX = 9606 GN = HBG1 PE = 1 SV = 2 Dysfunction of blood coagulation, Impairment of cellular oxidant detoxification, Disruption of hydrogen peroxide catabolic process
A0A182DWH4 1.8E−02 0.56 HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain OS = Homo sapiens OX = 9606 GN = HLA-DRB3 PE = 1 SV = 1 Impairment of antigen delivery to T cells and their activation, inability of T cells to proliferate and secrete cytokines which are normally involved in the immune response. Disruption of other parts of the immune response cascade, including B cells
P16455 2.6E−06 0.66 MGMT Methylated-DNA–protein-cysteine methyltransferase OS = Homo sapiens OX = 9606 GN = MGMT PE = 1 SV = 1 Inability to replicate DNA
O95864 4.6E−02 0.67 FADS2 Fatty acid desaturase 2 OS = Homo sapiens OX = 9606 GN = FADS2 PE = 1 SV = 1 Dysfunction of the skin barrier and changes in the structure of the fat structure in the stratum corneum
P69905 2.5E−02 0.68 HBA1 Hemoglobin subunit alpha OS = Homo sapiens OX = 9606 GN = HBA1 PE = 1 SV = 2 Disruption of the catabolic processes of hydrogen peroxide, oxidation–reduction, oxygen delivery to various tissues, disruption of the cell death, and small molecule metabolic process
P68871 4.3E−02 0.70 HBB Hemoglobin subunit beta OS = Homo sapiens OX = 9606 GN = HBB PE = 1 SV = 2 Disruption of the catabolic processes of hydrogen peroxide, oxidation–reduction, oxygen delivery to various tissues, disruption of the cell death, Disorder of small molecular metabolic process small molecule metabolic process, Dysregulation of nitric oxide biosynthetic process
Q9ULE0 8.0E−06 0.72 WWC3 Protein WWC3 OS = Homo sapiens OX = 9606 GN = WWC3 PE = 1 SV = 3 Increased cell proliferation and metastasis
O95969 3.2E−02 0.72 SCGB1D2 Secretoglobin family 1D member 2 OS = Homo sapiens OX = 9606 GN = SCGB1D2 PE = 2 SV = 1 Impaired inflammation modulation, tissue repair disorders and tumorigenesis, Disorder of cellular physiological process
O14556 1.6E−02 0.73 GAPDHS Glyceraldehyde-3-phosphate dehydrogenase, testis-specific OS = Homo sapiens OX = 9606 GN = GAPDHS PE = 1 SV = 2 Increased glycolytic metabolism, tumor progression and metastatic proliferation of tumor cells, Disruption of the various membrane, cytoplasmic and nuclear transmissions