Table 7 Summary of percentile PRS using IBS, EUR and ALL background distributions for each family member
From: Implementation of individualised polygenic risk score analysis: a test case of a family of four
| Â | PT00007A (Father) | PT00008A (Mother) | PT00009A (Daughter) | PT00002A (Son) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
IBS (n = 107) | EUR (n = 503) | ALL (n = 2504) | IBS (n = 107) | EUR (n = 503) | ALL (n = 2504) | IBS (n = 107) | EUR (n = 503) | ALL (n = 2504) | IBS (n = 107) | EUR (n = 503) | ALL (n = 2504) | |
Colorectal cancer | 99.07 | 97.42 | 99.36 | 86.92 | 79.92 | 88.94 | 99.07 | 97.22 | 98.96 | 98.13 | 91.05 | 95.25 |
Coronary artery disease | 30.84 | 29.62 | 44.69 | 99.07 | 96.62 | 96.17 | 94.39 | 89.86 | 88.78 | 86.92 | 81.91 | 81.99 |
Testicular cancer | 37.38 | 42.35 | 44.01 | 88.79 | 90.66 | 91.17 | 96.26 | 95.83 | 95.89 | 31.78 | 38.37 | 40.65 |
Glaucoma | 89.72 | 88.67 | 83.91 | 42.06 | 42.35 | 29.47 | 69.16 | 65.01 | 56.51 | 70.09 | 65.21 | 56.71 |
Thyroid cancer | 56.07 | 49.30 | 59.74 | 57.01 | 50.50 | 60.10 | 40.19 | 32.41 | 39.70 | 95.33 | 90.66 | 95.21 |
Prostate cancer | 51.40 | 50.50 | 40.06 | 81.31 | 80.91 | 62.86 | 91.59 | 92.45 | 72.96 | 22.43 | 21.67 | 16.57 |
Inflammatory bowel disease | 63.55 | 43.54 | 37.50 | 88.79 | 70.78 | 60.86 | 66.36 | 46.72 | 40.65 | 66.36 | 46.72 | 40.65 |
Breast cancer | 22.43 | 17.30 | 5.87 | 84.11 | 85.69 | 62.22 | 48.60 | 53.28 | 25.84 | 64.49 | 64.61 | 35.62 |
Chronic lymph leukaemia | 21.50 | 16.50 | 27.12 | 49.53 | 45.53 | 64.58 | 45.79 | 41.15 | 58.35 | 49.53 | 44.14 | 63.02 |
Basal Cell Carcinoma | 69.16 | 55.86 | 89.90 | 11.21 | 7.55 | 70.61 | 14.02 | 10.54 | 73.08 | 22.43 | 14.12 | 75.16 |
Type 2 diabetes | 50.47 | 60.44 | 13.62 | 64.49 | 71.37 | 16.29 | 62.62 | 68.79 | 15.58 | 34.58 | 45.33 | 9.90 |
Melanoma | 28.04 | 14.51 | 76.96 | 21.50 | 9.74 | 73.92 | 32.71 | 22.86 | 79.95 | 32.71 | 23.26 | 80.15 |
Ischaemic stroke | 22.43 | 26.24 | 5.59 | 88.79 | 82.90 | 28.67 | 65.42 | 64.02 | 18.41 | 38.32 | 38.17 | 8.67 |
Glioma | 0.93 | 4.57 | 13.26 | 49.53 | 42.35 | 64.70 | 23.36 | 18.69 | 39.90 | 3.74 | 5.96 | 15.69 |
Atrial fibrillation | 24.30 | 16.50 | 5.07 | 23.36 | 15.51 | 4.83 | 13.08 | 8.55 | 2.44 | 9.35 | 7.16 | 2.00 |