Table 2 Characteristics of the HbA2 reduce group and control group
From: RS12574989 and haplotype associated with α/β-chain imbalance and population HbA2 reduction
HbA2 under 2.5 group (n = 931) | HbA2 under 2.4 group (n = 165) | Control group (n = 183) | P value | ||||
|---|---|---|---|---|---|---|---|
HbA2 under 2.5 (n = 934) VS. HbA2 under 2.4 (n = 165) | HbA2 under 2.5 (n = 934) VS. Control (n = 183) | HbA2 under 2.4 (n = 165) VS. Control (n = 183) | |||||
Age | Mean ± SD | 32.87 ± 5.81 | 33.21 ± 5.67 | 32.46 ± 5.08 | |||
Range | 21–54 | 22–49 | 22–46 | 0.487 | 0.377 | 0.1953 | |
Gender [n(%)] | Male | 347(37.15) | 50(30.3) | 85(46.45) | |||
Female | 587(62.85) | 115(69.7) | 98(53.55) | 0.065 | 0.025 | < 0.001 | |
MCV [fL] | Mean ± SD | 88.10 ± 3.30 | 88.48 ± 3.39 | 88.34 ± 3.55 | |||
Range | 82–99.8 | 82.2–97.8 | 82–99.4 | 0.17 | 0.362 | 0.7118 | |
MCH [pg] | Mean ± SD | 30.12 ± 1.28 | 30.08 ± 1.24 | 30.24 ± 1.14 | |||
Range | 27–34.4 | 27.1–33.7 | 27.7–33.9 | 0.735 | 0.213 | 0.2007 | |
MCHC [g/dL] | Mean ± SD | 34.19 ± 0.99 | 34.04 ± 0.84 | 34.27 ± 0.83 | |||
Range | 31.2–38.1 | 31.7–36.3 | 32.1–36.5 | 0.068 | 0.325 | 0.0112 | |
RBC [10^12/L] | Mean ± SD | 4.64 ± 0.5 | 4.62 ± 0.46 | 4.74 ± 0.47 | |||
Range | 2.94–6.17 | 3.24–6.03 | 3.8–5.84 | 0.517 | 0.011 | 0.011 | |
Hb [g/dL] | Mean ± SD | 13.97 ± 1.51 | 13.9 ± 1.38 | 14.34 ± 1.4 | |||
Range | 8.7–18 | 9.9–18 | 11.5–17.5 | 0.573 | 0.003 | 0.0037 | |
RDW [%] | Mean ± SD | 12.6 ± 0.74 | 12.58 ± 0.83 | 12.44 ± 0.6 | |||
Range | 10.9–18.4 | 10.9–18.4 | 11.2–15.5 | 0.831 | 0.007 | 0.0646 | |