Table 3 Statistical analysis of the distribution of SNPs and haplotypes in the HbA2 reduce group and control group
From: RS12574989 and haplotype associated with α/β-chain imbalance and population HbA2 reduction
HbA2 under 2.4 group (n = 165) | Control group (n = 183) | OR[95%CI] | P value | |
|---|---|---|---|---|
rs 12574989 C/T | ||||
CC | 102(0.618) | 159(0.869) | 1 | |
CT | 57(0.345) | 23(0.126) | 3.863[2.242–6.658] | |
TT | 6(0.036) | 1(0.005) | 9.353[1.110–78.826] | < 0.001 |
CT + TT | 63(0.382) | 24(0.131) | 9.353[1.847–2.268] | < 0.001 |
C | 261(0.791) | 341(0.932) | ||
T | 69(0.209) | 25(0.068) | 17.613[1.007–1.259] | < 0.001 |
rs 7110263 T/G | ||||
TT | 44(0.267) | 50(0.273) | 1 | |
GT | 84(0.509) | 98(0.536) | 0.469[0.313–0.702] | |
GG | 37(0.224) | 35(0.191) | 0.365[0.212–0.630] | 0.746 |
G | 158(0.479) | 168(0.459) | ||
T | 172(0.521) | 198(0.541) | 1.083[0.804–1.459] | 0.602 |
rs 10837631 T/A | ||||
TT | 82(0.497) | 82(0.448) | 1 | |
AT | 66(0.400) | 84(0.459) | 0.786[0.504–1.226] | |
AA | 17(0.103) | 17(0.093) | 1[0.478–2.093] | 0.54 |
A | 100(0.303) | 118(0.322) | ||
T | 230(0.697) | 248(0.678) | 0.914[0.663–1.260] | 0.582 |
rs 78928216 A/C | ||||
AA | 109(0.661) | 135(0.738) | 1 | |
AC | 51(0.309) | 46(0.251) | 0.188[1.373–0.857] | |
CC | 5(0.030) | 2(0.011) | 0.182[3.096–0.589] | 0.183 |
A | 269(0.815) | 316(0.863) | ||
C | 61(0.185) | 50(0.137) | 0.698[0.464–1.049] | 0.083 |
rs 10837630 G/C | ||||
GG | 45(0.273) | 51(0.279) | 1 | |
CG | 82(0.497) | 96(0.525) | 0.898[0.968–0.589] | |
CC | 38(0.230) | 36(0.197) | 0.563[1.196–0.652] | 0.741 |
C | 158(0.479) | 168(0.459) | ||
G | 172(0.521) | 198(0.541) | 1.083[0.803–1.459] | 0.602 |
rs 11036351 C/T | ||||
CC | 110(0.667) | 136(0.743) | 1 | |
CT | 51(0.309) | 46(0.251) | 0.19[1.371–0.856] | |
TT | 4(0.024) | 1(0.005) | 0.155[4.945–0.545] | 0.143 |
C | 271(0.821) | 318(0.869) | ||
T | 59(0.179) | 48(0.131) | 0.693[0.458–1.049] | 0.082 |
Haplotype | ||||
C G A A C C | 96(0.291) | 112(0.306) | 0.906 [0.653–1.257] | 0.555 |
C G T C C T | 57(0.173) | 46(0.126) | 1.425 [0.935–2.173] | 0.098 |
C T T A G C | 101(0.306) | 170(0.464) | 0.487 [0.356–0.668] | < 0.001 |
T T T A G C | 69(0.209) | 24(0.066) | 3.710 [2.267–6.072] | < 0.001 |