Fig. 3

TME characteristics and immune landscapes under the three distinct tumor molecular subtypes. A Heatmap shows the ssGSEA score of representative Hallmark pathways curated from MSigDB in the three distinct tumor molecular subtypes. B Immune infiltration characteristics of the three tumor molecular subtypes based on ssGSEA algorithm. Tumor purity, ESTIMATE, immune and stromal scores from ESTIMATE algorithm are shown in annotations above. C Heatmap shows the ssGSEA score of representative immune signatures curated from other publications in the three distinct tumor molecular subtypes. The asterisks represented the statistical p value (*p < 0.05; **p < 0.01; ***p < 0.001). For comparisons of the three groups, the Kruskal–Wallis test was used