Table 1 Baseline clinic-biological characteristics of the patients included

All cases analyzed, %

7 (7.8%)

77 (85%)

4 (4.5%)

2 (2.2%)

90 (100%)

First diagnosis Progression/relapse

7 (100%)

41 (59%)

36 (41%)

3

1

2

0

90 (100%)

Age (years) mean

Range

65

(44–82)

63

(32–80)

67

(59 -73)

55

90 (100%)

Sex:

Female

Male

2 (29%)

5 (71%)

27 (36%)

49 (64%)

1 (25%)

3 (75%)

0

2 (100%)

90 (100%)

FC: % of PC

Mean

Range

0.70%

(0.04–2.6%)

10%

(0.002–83%)

0.80%

(0.1–1.9%)

1.30%

(0.003–2.6%)

90 (100%)

Mutation positive by NGS

2/7 (29%)

60/77 (78%)

1/4 (25%)

1/2 (50%)

90(100%)

Aspirate morphology: %

PC

Mean

Range

5%

(3–10%)

44%

(3–100%)

14%

(10–20%)

10%

90 (100%)

BM biopsy: %

PC

Mean

Range

7%

(1–10%)

48%

(< 1–100%)

9%

(5–15%)

10%

90 (100%)

Β2 microglobuline, mg/L

2.1

5.5

n/a

1.67

57/90 (63%)

M protein, g/dL

Mean

Range

9.22

(5.38–12)

35.6

(3.10- 367)

n/a

n/a

55/90 (60%)

Free light chains/serum mg/L

32.7

(14–58)

1140

(11–25,000)

56

465

80/90 (88%)

Mutation number by NGS

0

1

 > 1

5 (71%)

2 (29%)

0

13 (25%)

25 (47%)

15 (28%)

3 (75%)

1 (25%)

0

1(100%)

0

–

90 (100%)