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Table 3 Results of mediation analyses

From: Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations

SNP

Gene

Mediator

Outcome

Direct effect (95% CI)

Direct effect p value

Mediated effect (95% CI)

Mediated effect p value

Total effect (95% CI)

Total effect p value

rs11208712

Intergenic

CRP

BMI

− 0.12 (− 0.24, 0.00)

0.044

0.25 (0.19, 0.31)

< 0.01

0.12 (− 0.01, 0.26)

0.074

rs439401

APOE

WHR

CRP

0.64 (0.39, 0.88)

< 0.01

0.05 (0.01, 0.10)

0.024

0.69 (0.44, 0.94)

< 0.01

  1. Both variants rs11208712 and SNP rs439401 (APOE) illustrated direct association with CRP after adjusting for phenotypes that SNP was primarily associated in prior studies. Results suggest biologic pleiotropy with independent associations with both inflammation and obesity. SNP rs11208712 (LEPR) was not associated with BMI after adjusting for mediator (CRP), albeit missing on nominal significance by a close margin
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BMC Medical Genomics

ISSN: 1755-8794

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