Skip to main content

Table 3 Results of mediation analyses

From: Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations

SNP Gene Mediator Outcome Direct effect (95% CI) Direct effect p value Mediated effect (95% CI) Mediated effect p value Total effect (95% CI) Total effect p value
rs11208712 Intergenic CRP BMI − 0.12 (− 0.24, 0.00) 0.044 0.25 (0.19, 0.31) < 0.01 0.12 (− 0.01, 0.26) 0.074
rs439401 APOE WHR CRP 0.64 (0.39, 0.88) < 0.01 0.05 (0.01, 0.10) 0.024 0.69 (0.44, 0.94) < 0.01
  1. Both variants rs11208712 and SNP rs439401 (APOE) illustrated direct association with CRP after adjusting for phenotypes that SNP was primarily associated in prior studies. Results suggest biologic pleiotropy with independent associations with both inflammation and obesity. SNP rs11208712 (LEPR) was not associated with BMI after adjusting for mediator (CRP), albeit missing on nominal significance by a close margin