Fig. 1

Clinical manifestations of patients. A Patient 5 with a PIK3CA mutation with prominent superficial venous engorgement. The superficial venous engorgement showed improvement after 3 years of propranolol administration. B Patient 1 with a PIK3CA mutation showing port-wine stain of the skin and hypertrophy of the right leg. C Patient 10 with a PTEN mutation presented with epidermal nevus. The color of the epidermal nevus faded after 6 months of propranolol administration. D Patient 9 with a KRAS mutation showing hypertrophy of the right leg